3459-20-9

• 常用中文名：格列嘧啶钠
• 常用英文名：Glymidine sodium
• CAS号：3459-20-9
• 分子式：C₁₃H₁₄N₃NaO₄S
• 分子量：331.32300
• 相关类别： 原料药 激素及调节内分泌功能类药 胰腺激素及其它调节血糖药
• 发布时间：2018-04-16 08:00:00
• 更新时间：2024-01-02 17:27:49
• 格列米丁钠是一种口服活性降糖药。格列米丁钠是肝脏脂肪分解的抑制剂。Glymidine钠抑制葡萄糖的形成,并抑制因抑制内源性脂质动员而导致的丙酮酸氧化升高[1]。

名称

• 中文名: 格列嘧啶钠
• 英文名: sodium,benzenesulfonyl-[5-(2-methoxyethoxy)pyrimidin-2-yl]azanide
• 英文别名: Sodium glymidine; Glycanol; Glymidinum natricum; Redul IF; Glymidine sodique; Glimidina sodica; Sodium glycodiazine; Glycodiazine sodium; Redul sodium

物化性质

• 密度: 1.354g/cm3
• 沸点: 515.1ºC at 760mmHg
• 熔点: 221-226°
• 分子式: C₁₃H₁₄N₃NaO₄S
• 分子量: 331.32300
• 闪点: 265.4ºC
• 精确质量: 331.06000
• PSA: 90.00000
• LogP: 2.24220
• 储存条件: 2-8°C，干燥，密封

生物活性

• 描述: 格列米丁钠是一种口服活性降糖药。格列米丁钠是肝脏脂肪分解的抑制剂。Glymidine钠抑制葡萄糖的形成,并抑制因抑制内源性脂质动员而导致的丙酮酸氧化升高[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Menahan LA, et al. The role of endogenous lipid in gluconeogenesis and ketogenesis of perfused rat liver. Eur J Biochem. 1969;9(2):182-188.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DB2920000 CHEMICAL NAME : Benzenesulfonamide, N-(5-(2-methoxyethoxy)-2-pyrimidinyl)-, sodium salt CAS REGISTRY NUMBER : 3459-20-9 LAST UPDATED : 199309 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C13-H14-N3-O4-S.Na MOLECULAR WEIGHT : 331.35 WISWESSER LINE NOTATION : T6N CNJ BNSWR& EO2O1 &-NA- &24/10 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2850 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Endocrine - hypoglycemia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,377,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3120 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,221,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,221,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Endocrine - hypoglycemia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,377,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5300 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Endocrine - hypoglycemia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,377,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3210 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,221,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3340 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,221,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1480 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Endocrine - hypoglycemia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,377,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7800 mg/kg/78W-I TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,389,1964 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 52 gm/kg SEX/DURATION : multigenerations TOXIC EFFECTS : Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,389,1964

安全

• 危害码 (欧洲): Xi