183718-77-6

183718-77-6结构式

常用中文名：AM404
常用英文名：AM404
CAS号：183718-77-6
分子式：C₂₆H₃₇NO₂
分子量：395.578
相关类别：研究领域神经疾病
发布时间：2017-03-23 08:57:21
更新时间：2024-01-08 12:16:17
AM404是一种内源性大麻素再摄取抑制剂,在低微摩尔范围内阻断阿难酰胺的IC50值运输[1]。AM404能够松弛用苯肾上腺素收缩的大鼠离体肝动脉,pEC50值为7.4(对应于0.04µM的EC50)。神经保护作用[2]。

化源商城直购

英文名	N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide
英文别名	N-(4-Hydroxyphenyl)-arachidonylamide 5,8,11,14-Eicosatetraenamide, N-(4-hydroxyphenyl)-, (5Z,8Z,11Z,14Z)- AM 404 (5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)icosa-5,8,11,14-tetraenamide N-(4-Hydroxyphenyl)arachidonylamide AM-404 AM404 (5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)-5,8,11,14-icosatetraenamide

描述	AM404是一种内源性大麻素再摄取抑制剂,在低微摩尔范围内阻断阿难酰胺的IC50值运输[1]。AM404能够松弛用苯肾上腺素收缩的大鼠离体肝动脉,pEC50值为7.4(对应于0.04µM的EC50)。神经保护作用[2]。
相关类别	信号通路 >> 其他 >> 其他研究领域 >> 神经疾病
体外研究	AM404的IC50值为4.9µM,可减少C6胶质瘤细胞增殖。AM404在用于阻止内源性大麻素anandamide的细胞聚集的浓度下,非特异性地抑制C6胶质瘤细胞增殖[2]。细胞活性测定[2]细胞系：大鼠C6胶质瘤细胞浓度：1,3,10和30µM培养时间：24,48,72和96 h结果：在暴露于10和30µM浓度的24 h和暴露于3µM浓度的48 h后,细胞增殖产生浓度依赖性降低,在72小时时,细胞增殖显著减少,尽管很小。
体内研究	AM404(1-5) mg/kg,i.p.)在三种模型中发挥剂量依赖性抗焦虑作用：高架+迷宫、防御性戒断和分离诱导的超声波发声。动物模型：成年雄性Sprague-Dawley大鼠(250-300只) g) [2]剂量：2.5-10 mg/kg给药：腹腔注射(i.p.)结果：导致前额叶皮质、海马和丘脑中的阿南达胺水平呈剂量依赖性增加。
参考文献	[1]. A Giuffrida, et al. Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology. J Pharmacol Exp Ther. 2001 Jul;298(1):7-14. [2]. Kent-Olov Jonsson, et al. AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. Arch Toxicol. 2003 Apr;77(4):201-7. [3]. Marco Bortolato, et al. Anxiolytic-like properties of the anandamide transport inhibitor AM404. Neuropsychopharmacology. 2006 Dec;31(12):2652-9.

密度	1.0±0.1 g/cm3
沸点	579.4±50.0 °C at 760 mmHg
分子式	C₂₆H₃₇NO₂
分子量	395.578
闪点	304.2±30.1 °C
精确质量	395.282440
PSA	49.33000
LogP	7.63
蒸汽压	0.0±1.7 mmHg at 25°C
折射率	1.555
储存条件	-20°C，密闭，干燥

SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name: N-(4-Hydroxyphenyl)-arachidonylamide
REACH No.: A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later

registration deadline.
CAS-No.: 183718-77-6
Relevant identified uses of the substance or mixture and uses advised against
Identified uses: Laboratory chemicals, Manufacture of substances

SECTION 2: Hazards identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 2), H225
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
F Highly flammableR11
For the full text of the R-phrases mentioned in this Section, see Section 16.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal wordDanger
Hazard statement(s)
H225Highly flammable liquid and vapour.
Precautionary statement(s)
P210Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Supplemental Hazardnone
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)F Highly flammable
R-phrase(s)
R11Highly flammable.
S-phrase(s)
S16Keep away from sources of ignition - No smoking.
Caution - this mixture contains a substance not yet fully tested.
Other hazards - none

SECTION 3: Composition/information on ingredients
Mixtures
Synonyms: AM404
Formula: C26H37NO2 C26H37NO2
Molecular Weight: 395,58 g/mol
No components need to be disclosed according to the applicable regulations.
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available

SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
Use water spray to cool unopened containers.

SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.
Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
form explosive concentrations. Vapours can accumulate in low areas.
For personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
place in container for disposal according to local regulations (see section 13).
Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage
Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
charge.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Recommended storage temperature: -20 °C
Specific end use(s)
A part from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Impervious clothing., Flame retardant antistatic protective clothing, The type of protective
equipment must be selected according to the concentration and amount of the dangerous
substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) AppearanceForm: liquid
b) Odourno data available
c) Odour Thresholdno data available
d) pHno data available
e) Melting point/freezingno data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point14 °C - closed cup
h) Evaporation rateno data available
i) Flammability (solid, gas) no data available
j) Upper/lowerno data available
flammability or
explosive limits
k) Vapour pressureno data available
l) Vapour densityno data available
m) Relative densityno data available
n) Water solubilityno data available
o) Partition coefficient: n- no data available
octanol/water
p) Auto-ignitionno data available
temperature
q) Decompositionno data available
temperature
r) Viscosityno data available
s) Explosive propertiesno data available
t) Oxidizing propertiesno data available
Other safety information
no data available

SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
Heat, flames and sparks. Extremes of temperature and direct sunlight.
Incompatible materials
Oxidizing agents, Alkali metals, Ammonia, Peroxides
Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5

SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC:No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: Not available
Central nervous system depression, narcosis, Nausea, Dizziness, Damage to the heart., To the best of our
knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Heart - Irregularities - Based on Human Evidence

SECTION 12: Ecological information
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available

SECTION 13: Disposal considerations
Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
company.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information
UN number
ADR/RID: 1170IMDG: 1170IATA: 1170
UN proper shipping name
ADR/RID: ETHANOL
IMDG: ETHANOL
IATA:Ethanol
Transport hazard class(es)
ADR/RID: 3IMDG: 3IATA: 3
Packaging group
ADR/RID: IIIMDG: IIIATA: II
Environmental hazards
ADR/RID: noIMDG Marine Pollutant: noIATA: no
Special precautions for user
no data available

SECTION 15 - REGULATORY INFORMATION
N/A

SECTION 16 - ADDITIONAL INFORMATION
N/A

符号	GHS02, GHS07
信号词	Danger
危害声明	H225-H319
警示性声明	P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235
个人防护装备	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危害码 (欧洲)	F: Flammable;
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	S7
危险品运输编码	UN 1170 3/PG 2