96346-61-1

• 常用中文名：奥那司酮
• 常用英文名：Onapristone
• CAS号：96346-61-1
• 分子式：C₂₉H₃₉NO₃
• 分子量：449.62500
• 发布时间：2018-03-13 08:00:00
• 更新时间：2024-01-06 13:06:11
• A synthetic, steroidal progesterone receptor (PR) antagonist with reduced antiglucocorticoid activity compared to mifepristone..

名称

• 中文名: 奥那司酮
• 英文名: (8S,11R,13R,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
• 英文别名: Onapristonum [Latin]; ZK 299; Onapristona [Spanish]; Onapristone; Onapristone (INN)

物化性质

• 密度: 1.19 g/cm3
• 沸点: 654.8ºC at 760 mmHg
• 分子式: C₂₉H₃₉NO₃
• 分子量: 449.62500
• 闪点: 349.8ºC
• 精确质量: 449.29300
• PSA: 60.77000
• LogP: 5.15570
• 折射率: 1.615

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KG2945000 CHEMICAL NAME : Estra-4,9-dien-3-one, 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(3-hydroxy propyl)-, (11-beta,13-alpha,17-alpha)- CAS REGISTRY NUMBER : 96346-61-1 LAST UPDATED : 199607 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C29-H39-N-O3 MOLECULAR WEIGHT : 449.69 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 5 mg/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 40,549,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 18 mg/kg SEX/DURATION : female 3 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 35,409,1987 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 100 mg/kg SEX/DURATION : female 30-33 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 41,197,1990 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 40 mg/kg SEX/DURATION : female 8-11 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 52,187,1995