5118-29-6

5118-29-6结构式
5118-29-6结构式
  • 常用中文名:美利蒽
  • 常用英文名:Melitracen
  • CAS号:5118-29-6
  • 分子式:C21H25N
  • 分子量:291.43000
  • 相关类别: 原料药 神经系统用药 抗抑郁、躁狂药
  • 发布时间:2018-09-27 13:51:46
  • 更新时间:2024-01-12 18:30:18
  • 美利曲辛(Melitracene)是一种口服活性三环抗抑郁药,也是一种具有激活特性的双极性胸腺肽。美利曲辛抑制3H-5-HT和14H-5-HT,IC50分别为670nm和5500nm。美利曲辛可用于研究抑郁和焦虑[1][2]。

化源商城直购

中文名 美利蒽
英文名 3-(10,10-dimethylanthracen-9-ylidene)-N,N-dimethylpropan-1-amine
中文别名 二甲胺丙烯蒽
3-[10,10-二甲基-9(10H)-蒽亚基]-N,N-二甲基-1-丙胺
英文别名 Melitracen
Melitracene
Adaptol
Thymeol
Trausabun
Meltiracene
9.9-Dimethyl-10-<3-dimethylamino-propyliden>-9.10-dihydro-anthracen
Dixeran
描述 美利曲辛(Melitracene)是一种口服活性三环抗抑郁药,也是一种具有激活特性的双极性胸腺肽。美利曲辛抑制3H-5-HT和14H-5-HT,IC50分别为670nm和5500nm。美利曲辛可用于研究抑郁和焦虑[1][2]。
相关类别
靶点

IC50: 670 nM (3H-5-HT), 5500 nM (14H-5-HT)[2]

体外研究 美利曲辛(0-10μM;10分钟)抑制突触体中的3H-5-HT和血小板中的14H-5-HT[2]。细胞活力测定[2]细胞系:雄性白化大鼠的突触体和血小板浓度:0-10μM孵育时间:10分钟结果:突触体中的3H-5-HT和血小板中的14H-5-HT分别受到抑制,IC50分别为670 nM和5500 nM。
体内研究 美利曲辛(10-90 mg/kg;每日口服3个月)影响大鼠的行为、体重和生长[1]。动物模型:雄性和雌性Wistar大鼠[1]剂量:10、30和90mg/kg给药:口服灌胃;每日10-90mg/kg;3个月的结果:随着剂量的增加,大鼠表现出攻击性行为、兴奋性、身体和肝脏重量增加,肝脏轻微萎缩。
参考文献

[1]. Shimamoto K, et al. Relationship between the restriction of food intake and Melitracen, an antidepressant, in the rat. Acta Sch Med Univ Kioto. 1967 Jul;40(1):25-37.

[2]. Hyttel J. Effect of a specific 5-HT uptake inhibitor, citalopram (Lu 10-171), on 3H-5-HT uptake in rat brain synaptosomes in vitro. Psychopharmacology (Berl). 1978 Dec 15;60(1):13-8. doi: 10.1007/BF00429172. PMID: 104340.

密度 1.046g/cm3
沸点 399.1ºC at 760mmHg
分子式 C21H25N
分子量 291.43000
闪点 174.4ºC
精确质量 291.19900
PSA 3.24000
LogP 4.70930
折射率 1.4900 (estimate)
储存条件 库房通风低温干燥,与食品原料分开存放

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CB0770000
CHEMICAL NAME :
delta-(sup 9(10),gamma)-Anthracenepropylamine, N,N,10,10-tetramethyl-
CAS REGISTRY NUMBER :
5118-29-6
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C21-H25-N
MOLECULAR WEIGHT :
291.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
96 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
315 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
131 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
52 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970

海关编码 2921499090

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5118-29-6结构式

5118-29-6

文献:Holm,T. Acta Chemica Scandinavica (1947-1973), 1963 , vol. 17, p. 2437 - 2443
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海关编码 2921499090
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