81279-39-2

• 常用中文名：5'-O-[双(4-甲氧基苯基)苯基甲基]-2'-O-[(叔丁基)二甲基硅基]-N-(2-甲基-1-氧代丙基)鸟苷
• 常用英文名：5'-O-DMT-2'-O-iBu-N-Bz-Guanosine
• CAS号：81279-39-2
• 分子式：C₄₁H₅₁N₅O₈Si
• 分子量：769.95800
• 相关类别： 研究领域 其他
• 发布时间：2019-01-03 12:16:16
• 更新时间：2024-01-07 09:04:54
• 5'-O-DMT-2'-O-iBu-N-Bz-鸟苷可用于核糖核苷的硅基保护[1]。

名称

• 中文名: 5'-O-[双(4-甲氧基苯基)苯基甲基]-2'-O-[(叔丁基)二甲基硅基]-N-(2-甲基-1-氧代丙基)鸟苷
• 英文名: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-6-oxo-3H-purin-2-yl]-2-methylpropanamide
• 英文别名: 5'-dimethoxytrityl 2'-tert-butyldimethyl silyl N-isobutyrylguanosine; (2)N-isobutyryl-5'O-dimetoxytrityl-3'O-tert-butyldimethylsilyl guanosine; 5'-O-DMT-2'-O-iBu-N-Bz-Guanosine; 5'-O-DMT-N-isobutyryl-2'-O-TBDMS-guanosine; N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-tert-butyldimethylsilyl guanosine; N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide; 2-N-isobutyryl-2'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)guanosine; 5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N2-isobutyryl guanosine

物化性质

• 密度: 1.25
• 分子式: C₄₁H₅₁N₅O₈Si
• 分子量: 769.95800
• 精确质量: 769.35100
• PSA: 159.31000
• LogP: 6.87400
• 储存条件: 室温，干燥

生物活性

• 描述: 5'-O-DMT-2'-O-iBu-N-Bz-鸟苷可用于核糖核苷的硅基保护[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Thomas P Blaisdell, et al. Practical silyl protection of ribonucleosides. Org Lett. 2013 Sep 20;15(18):4710-3.

安全

• 危害码 (欧洲): Xi

合成路线

18162-48-6 81246-83-5 ~61% 81279-39-2 81256-89-5

文献：Wexselblatt, Ezequiel; Katzhendler, Jehoshua; Saleem-Batcha, Raspudin; Hansen, Guido; Hilgenfeld, Rolf; Glaser, Gad; Vidavski, Roee R. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 12 p. 4485 - 4497

18162-48-6 81246-83-5 ~74% 81279-39-2

文献：Blaisdell, Thomas P.; Lee, Sunggi; Kasaplar, Pinar; Sun, Xixi; Tan, Kian L. Organic Letters, 2013 , vol. 15, # 18 p. 4710 - 4713

40615-36-9 182007-86-9 ~88% 81279-39-2

文献：Serebryany; Beigelman Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009

118-00-3 ~% 81279-39-2

文献：Serebryany; Beigelman Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009

126628-29-3 ~% 81279-39-2

文献：Serebryany; Beigelman Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009

401812-99-5 ~% 81279-39-2

文献：Serebryany; Beigelman Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009

401813-00-1 ~% 81279-39-2

文献：Serebryany; Beigelman Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009

64350-24-9 ~% 81279-39-2

文献：Glaser, Gad; Katzhendler, Jehoshua; Hilgenfeld, Rolf; Vidavski, Roee; Wexselblatt, Ezequiel; Prez-Menahemov, Tamar; Kaspy, Ilana Patent: US2011/86813 A1, 2011 ;

上下游产品

上游产品  6
18162-48-6 81246-83-5 40615-36-9 118-00-3
126628-29-3 64350-24-9
下游产品  1
147201-04-5