34785-00-7

• 常用中文名：羟基脱氢硝苯地平内酯
• 常用英文名：Hydroxy Dehydro Nifedipine Lactone
• CAS号：34785-00-7
• 分子式：C₁₆H₁₂N₂O₆
• 分子量：328.27600
• 发布时间：2017-08-20 13:58:14
• 更新时间：2025-08-27 19:59:47

名称

• 中文名: 羟基脱氢硝苯地平内酯
• 英文名: Hydroxy Dehydro Nifedipine Lactone
• 中文别名: 硝苯地平杂质12; 硝苯地平杂质12中间体; 羟基去氢硝苯地平内酯
• 英文别名: 4-(2-Nitrophenyl)-2-(hydroxyMethyl)-5-(Methoxycbonyl)-6- Methylpyridine-3-cboxylic Acid-γ-lactone; methyl 2-methyl-4-(2-nitrophenyl)-5-oxo-7H-furo[3,4-b]pyridine-3-carboxylate; 2-Hydroxymethyl-5-(methoxycbonyl)-6-methyl-4-(2-nitrophenyl)pyridine-3-cboxylic Acid Lactone (Hy; 5,7-Dihydro-2-Methyl-4-(2-nitrophenyl)-5-oxo-furo[3,4-b]pyridine-3-cboxylic acid Methyl Ester; methyl 2-methyl-4-(2-nitrophenyl)-5-oxo-5,7-dihydrofuro[3,4-b]pyridine-3-cboxylate; Furo[3,4-b]pyridine-3-cboxylic acid, 5,7-dihydro-2-methyl-4-(2-nitrophenyl)-5-oxo-, methyl ester; Nifedipine Dehydro Hydroxy Lactone; 2-Hydroxymethyl-5-(methoxycbonyl)-6-methyl-4-(2-nitrophenyl)pyridine-3-cboxylic Acid Lactone (Hydroxy Dehydro Nifedipine Lactone); Nifedipine impurity 12; Hydroxy dehydro Nifedipine

物化性质

• 分子式: C₁₆H₁₂N₂O₆
• 分子量: 328.27600
• 精确质量: 328.07000
• PSA: 111.31000
• LogP: 2.94540

合成路线

92089-09-3 ~94% 34785-00-7

文献：Goerlitzer; Dobberkau; Ewert; Heinrici; Bartke; Buss; Kupfer; Nuhn Pharmazie, 1997 , vol. 52, # 8 p. 575 - 578

113817-49-5 ~66% 34785-00-7

文献：Skrastin'sh, I. P.; Kastron, V. V.; Dubur, G. Ya.; Mazheika, I. B.; Kadysh, V. P. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 9 p. 981 - 985 Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 9 p. 1227 - 1232

67035-22-7 ~% 34785-00-7

文献：Kondo; Kuchiki; Yamamoto; Akimoto; Takahashi; Awata; Sugimoto Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 1 p. 1 - 7

105378-60-7 ~25% 34785-00-7

文献：Gorlitzer; Bartke; Buss; Duwel Archiv der Pharmazie, 1986 , vol. 319, # 6 p. 527 - 530

21829-25-4 ~% 34785-00-7

文献：Skrastin'sh, I. P.; Kastron, V. V.; Dubur, G. Ya.; Mazheika, I. B.; Kadysh, V. P. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 9 p. 981 - 985 Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 9 p. 1227 - 1232

87191-97-7 ~% 34785-00-7

文献：Goerlitzer; Dobberkau; Ewert; Heinrici; Bartke; Buss; Kupfer; Nuhn Pharmazie, 1997 , vol. 52, # 8 p. 575 - 578

14205-39-1 ~% 34785-00-7

文献：Goerlitzer; Dobberkau; Ewert; Heinrici; Bartke; Buss; Kupfer; Nuhn Pharmazie, 1997 , vol. 52, # 8 p. 575 - 578

上下游产品

上游产品  6
113817-49-5 67035-22-7 105378-60-7 21829-25-4
87191-97-7 14205-39-1
下游产品  1
34783-31-8