114676-67-4

• 常用中文名：(2S,4R)-1-Boc-4-(叔丁基二甲基硅氧基)-2-(羟甲基)吡咯烷
• 常用英文名：(2S,4R)-1-Boc-4-(tert-butyldimethylsilyloxy)-2-(hydroxyMethyl)pyrrolidine
• CAS号：114676-67-4
• 分子式：C₁₆H₃₃NO₄Si
• 分子量：331.52300
• 发布时间：2018-12-25 10:52:30
• 更新时间：2025-10-24 17:56:04

名称

• 中文名: (2S,4r)-1-boc-4-(叔丁基二甲基甲硅烷基氧基)-2-(羟基甲基)吡咯烷
• 英文名: 2-Methyl-2-propanyl (2S,4R)-4-{[dimethyl(2-methyl-2-propanyl)sily l]oxy}-2-(hydroxymethyl)-1-pyrrolidinecarboxylate
• 中文别名: (2S,4R)-1-Boc-4-(叔丁基二甲基硅氧基)-2-(羟甲基)吡咯烷
• 英文别名: Simvastatin Acid Ammonium Salt; simvastatin hydroxy acid,ammonium salt; Simvastatin acid ammonium

物化性质

• 分子式: C₁₆H₃₃NO₄Si
• 分子量: 331.52300
• 精确质量: 331.21800
• PSA: 59.00000
• LogP: 3.31640
• 储存条件: 室温，干燥

合成路线

114676-91-4 ~95% 114676-67-4

文献：Elsohly, Adel M.; Wespe, Daniel A.; Poore, Tyler J.; Snyder, Scott A. Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5789 - 5794 Angew. Chem., 2013 , vol. 125, # 22 p. 5901 - 5906,7

753014-18-5 ~93% 114676-67-4

文献：APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. Patent: WO2004/76407 A2, 2004 ; Location in patent: Page 27-29 ; WO 2004/076407 A2

24424-99-5 ~% 114676-67-4

文献：Fujisawa Pharmaceutical Co., Ltd. Patent: US4822787 A1, 1989 ;

18162-48-6 ~% 114676-67-4

文献：ROTTAPHARM S.P.A.; STASI, Luigi, Piero; ROVATI, Lucio Patent: WO2011/6960 A1, 2011 ; WO 2011/006960 A1

74844-91-0 ~% 114676-67-4

文献：ROTTAPHARM S.P.A.; STASI, Luigi, Piero; ROVATI, Lucio Patent: WO2011/6960 A1, 2011 ; WO 2011/006960 A1

40216-83-9 ~% 114676-67-4

文献：Fransson, Rebecca; McCracken, Alison N.; Chen, Bin; McMonigle, Ryan J.; Edinger, Aimee L.; Hanessian, Stephen ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 10 p. 969 - 973

1499-56-5 ~% 114676-67-4

文献：Zheng, Bo; Wang, Hui; Han, Yong; Liu, Changlu; Peng, Yungui Chemical Communications, 2013 , vol. 49, # 40 p. 4561 - 4563

51-35-4 ~% 114676-67-4

文献：Zheng, Bo; Wang, Hui; Han, Yong; Liu, Changlu; Peng, Yungui Chemical Communications, 2013 , vol. 49, # 40 p. 4561 - 4563

13726-69-7 ~% 114676-67-4

文献：Elsohly, Adel M.; Wespe, Daniel A.; Poore, Tyler J.; Snyder, Scott A. Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5789 - 5794 Angew. Chem., 2013 , vol. 125, # 22 p. 5901 - 5906,7

上下游产品

上游产品  8
114676-91-4 24424-99-5 18162-48-6 74844-91-0
40216-83-9 1499-56-5 51-35-4 13726-69-7
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114676-93-6