33103-22-9

• 常用中文名：恩维霉素
• 常用英文名：Enviomycin
• CAS号：33103-22-9
• 分子式：C₂₅H₄₃N₁₃O₁₀
• 分子量：685.69000
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-06-19 18:01:04
• 更新时间：2024-01-14 10:20:54
• 环境霉素是一种抗菌抗生素。环境霉素已用于研究慢性空洞性肺结核[1]。

名称

• 中文名: 恩维霉素
• 英文名: 3,6-diamino-N-[(6E)-3-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-6-[(carbamoylamino)methylidene]-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazacyclohexadec-15-yl]-4-hydroxyhexanamide
• 英文别名: Tuberactinomycin N; Tuberactinomycin A; Tuberactinomycin; Viomycin,1-(L-threo-3,6-diamino-4-hydroxyhexanoic acid); (3R,4R)-3,6-diamino-4-hydroxy-hexanoyl->-cyclo-[L-2,3-diamino-propionyl->-L-seryl->-L-seryl->-(Z)-2-amino-3-ureido-acryloyl->-(S)-amino-((R)-2-amino-1(3),4,5,6-tetrahydro-pyrimidin-4-yl)-acetyl-(1->N3)]; C25H43N13O11; 1-(L-threo-3,6-Diamino-4-hydroxyhexanoic acid)viomycin; 3,6-diamino-4-hydroxy-hexanoyl->-cyclo-[L-2,3-diamino-propionyl->-L-seryl->-L-seryl->-2-amino-3-ureido-acryloyl->-(S)-amino-((4R)-2-amino-6t-hydroxy-1(3),4,5,6-tetrahydro-pyrimidin-4r-yl)-acetyl-(1->N3)]

物化性质

• 密度: 1.8g/cm3
• 分子式: C₂₅H₄₃N₁₃O₁₀
• 分子量: 685.69000
• 精确质量: 685.32600
• PSA: 412.29000
• 折射率: 1.762

生物活性

• 描述: 环境霉素是一种抗菌抗生素。环境霉素已用于研究慢性空洞性肺结核[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点:

  Mycobacterium tuberculosis[1]

• 体外研究: 环境霉素对结核分枝杆菌H37Rv株、鸟分枝杆菌细胞内复合物(MAI复合物)13008、13016和11004株具有抗菌活性,MIC分别为12.5μg/mL、3.2μg/mL,6.3μg/mL和12.5μg/mL[1]。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : ZA3930000 CHEMICAL NAME : Viomycin, 1-(threo-4-hydroxy-L-3,6-diaminohexanoic acid)-6-(L-2-(2-amino-1,4,5,6-tetrahydro- 4-pyrimidinyl)glycine)-, (R)- CAS REGISTRY NUMBER : 33103-22-9 LAST UPDATED : 199506 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C25-H43-N13-O10 MOLECULAR WEIGHT : 685.81 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 640 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 370 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975