289042-10-0

• 常用中文名：瑞舒伐他汀中间体Z-8.1
• 常用英文名：Methanesulfonamide,N-[5-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl
• CAS号：289042-10-0
• 分子式：C₂₈H₂₉FN₃O₃PS
• 分子量：537.585
• 发布时间：2018-08-09 12:07:34
• 更新时间：2024-01-08 20:43:40

名称

• 中文名: N-[5-(联苯-膦酰基甲基)-4-(4-氟-苯基)-6-异丙基-嘧啶-2-基]-N-甲基-甲烷磺胺
• 英文名: N-[5-(diphenylphosphorylmethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide
• 中文别名: 罗苏伐他汀 中间体ZD-9; 4-(4-氟苯基)-5-三苯基磷溴-6-异丙基-2-[(N-甲基-N-甲磺酰胺基)]-嘧啶; N-[4-(4-氟苯基)-5-(二苯基氧膦基)甲基-6-异丙基-2-嘧啶基]-N-甲基甲磺酰胺基; N-[5-(二苯基膦酰甲基)-4-(4-氟苯基)-6-异丙基嘧啶-2-基]-N-甲基甲磺酰胺; N-[5-(二苯基膦酰甲基)-4-(4-氟苯基)-6-异丙基嘧啶-2-基]-N-甲基甲磺酰胺; 瑞舒伐他汀钙中间体
• 英文别名: Methanesulfonamide, N-[5-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-; N-{5-[(Diphenylphosphoryl)methyl]-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl}-N-methylmethanesulfonamide; diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-ylmethyl]phosphine oxide; N-[5-(diphenyl-phosphinoylmethyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide; N-{5-[(diphenylphosphoryl)methyl]-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl}-N-methylmethanesulfonamide; diphenyl [4-(4-fluoropheny)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-ylmethyl] phosphine oxide; N-[5-[(diphenylphosphinoyl)-methyl]-4-(4-fluorophenyl)-6-isopropyl-pyrimidindin-2-yl]-N-methyl-methanesulfonamide; diphenyl[2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-ylmethyl]phosphine oxide; N-{5-[(Diphenylphosphoryl)methyl]-4-(4-fluorphenyl)-6-(propan-2-yl)pyrimidin-2-yl}-N-methylmethansulfonamid; AC-3407; N-{5-[(Diphenylphosphoryl)methyl]-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl}-N-methylmethanesulfonamide; N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide; Methanesulfonamide,N-[5-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 679.1±65.0 °C at 760 mmHg
• 分子式: C₂₈H₂₉FN₃O₃PS
• 分子量: 537.585
• 闪点: 364.5±34.3 °C
• 精确质量: 537.165100
• PSA: 98.42000
• LogP: 3.21
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.625
• 储存条件: 室温，保存在惰性气体中

合成路线

799842-07-2 719-80-2 ~71% 289042-10-0

文献：WO2004/103977 A2, ; Page 24-25 ;

289042-11-1 719-80-2 ~% 289042-10-0

文献：US2004/49036 A1, ; Page 2; 3 ;

1079-66-9 147118-36-3 ~24% 289042-10-0

文献：US6160115 A1, ;

147118-36-3 ~% 289042-10-0

文献：US6160115 A1, ;

147118-30-7 ~% 289042-10-0

文献：WO2012/2741 A2, ; WO 2012/002741 A2

925422-06-6 ~% 289042-10-0

文献：WO2012/2741 A2, ; WO 2012/002741 A2

上下游产品

上游产品  6
799842-07-2 719-80-2 289042-11-1 1079-66-9
147118-36-3 147118-30-7
下游产品  2
503610-43-3 289042-12-2