799842-07-2

• 常用中文名：瑞舒伐他中间体Z-8
• 常用英文名：N-[5-bromomethyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide
• CAS号：799842-07-2
• 分子式：C₁₆H₁₉BrFN₃O₂S
• 分子量：416.308
• 发布时间：2018-05-09 08:00:00
• 更新时间：2024-01-04 20:29:45

名称

• 中文名: 5-(溴甲基)-4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]嘧啶
• 英文名: N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide
• 中文别名: 4-(4-氟苯基)-5-溴甲基-6-异丙基-2-[(N-甲基-N-甲磺酰胺基)]-嘧啶; N-[4-(4-氟苯基)-5-溴甲基-6-异丙基-2-嘧啶基]-N-甲基甲磺酰胺; 瑞舒伐他中间体Z-8; 瑞舒伐他汀钙中间体
• 英文别名: N-[5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl]-N-methylmethanesulfonamide; Methanesulfonamide, N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-; N-[5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide; N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide; N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide; 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine; 5-(BROMOMETHYL)-4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(METHYL(MET HYLSULFONYL)AMINO)PYRIMIDINE; N-[5-bromomethyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 531.2±60.0 °C at 760 mmHg
• 分子式: C₁₆H₁₉BrFN₃O₂S
• 分子量: 416.308
• 闪点: 275.0±32.9 °C
• 精确质量: 415.036530
• PSA: 71.54000
• LogP: 2.61
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.586
• 储存条件: 2-8°C，保存于惰性气体中

合成路线

925422-06-6 ~96% 799842-07-2

文献：YUHAN CORPORATION; JU, Hyun; JOUNG, Sang-Sun; YI, Hyun-Jik; KHOO, Ja-Heouk; LIM, Jong-Chul; KIM, Jae-Gyu Patent: WO2012/2741 A2, 2012 ; Location in patent: Page/Page column 19 ; WO 2012/002741 A2

147118-36-3 ~10% 799842-07-2

文献：Kaneka Corporation Patent: EP2351762 A1, 2011 ; Location in patent: Page/Page column 9 ;

953776-62-0 ~90% 799842-07-2

文献：LEK PHARMACEUTICALS D.D.; CASAR, Zdenko; STERK, Damjan; JUKIC, Marko Patent: WO2012/13325 A1, 2012 ; Location in patent: Page/Page column 57-58 ;

114433-94-2 ~% 799842-07-2

文献：WO2012/13325 A1, ;

1354455-77-8 ~% 799842-07-2

文献：WO2012/13325 A1, ;

1207460-34-1 ~% 799842-07-2

文献：WO2012/13325 A1, ;

147118-30-7 ~% 799842-07-2

文献：WO2012/2741 A2, ; WO 2012/002741 A2

上下游产品

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