52794-97-5

• 常用中文名：卡柔比星盐酸盐
• 常用英文名：Carubicin Hydrochloride
• CAS号：52794-97-5
• 分子式：C₂₆H₂₈ClNO₁₀
• 分子量：549.954
• 相关类别： 信号通路 细胞凋亡 细胞凋亡
• 发布时间：2018-04-12 08:00:00
• 更新时间：2024-01-09 21:54:28
• 盐酸卡柔比星是一种微生物衍生化合物。盐酸卡柔比星是VHL缺陷型(VHL)的有效抑制剂−/−) CCRCC细胞增殖。盐酸卡柔比星也通过独立于p53或缺氧诱导因子HIF2的机制诱导细胞凋亡。盐酸卡柔比星具有研究癌症疾病的潜力[1][2]。

名称

• 中文名: 卡柔比星盐酸盐
• 英文名: Karminomycin hydrochloride
• 英文别名: Carubicin Hydrochloride; 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8S,10S)-, hydrochloride (1:1); (1S,3S)-3-Acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside hydrochloride (1:1); Carminomycin hydrochloride; (1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,10,12-tetrahydroxy-6,11-dioxo-1-naphthacenyl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside hydrochloride; Karminomycin hydrochloride; Caminomycin hydrochloride; 5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, hydrochloride, (8S-cis)-

物化性质

• 密度: 1.63g/cm3
• 沸点: 750.6ºC at 760mmHg
• 分子式: C₂₆H₂₈ClNO₁₀
• 分子量: 549.954
• 闪点: 407.7ºC
• 精确质量: 549.140198
• PSA: 196.84000
• LogP: 2.22820

生物活性

• 描述: 盐酸卡柔比星是一种微生物衍生化合物。盐酸卡柔比星是VHL缺陷型(VHL)的有效抑制剂−/−) CCRCC细胞增殖。盐酸卡柔比星也通过独立于p53或缺氧诱导因子HIF2的机制诱导细胞凋亡。盐酸卡柔比星具有研究癌症疾病的潜力[1][2]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 感染
• 参考文献:

  [1]. Woldemichael GM, et al. Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells. Cancer Res. 2011 Jan 1;71(1):134-42.

  [2]. Tevyashova AN, et al. Carminomycin, 14-hydroxycarminomycin and its novel carbohydrate derivatives potently kill human tumor cells and their multidrug resistant variants. J Antibiot (Tokyo). 2004 Feb;57(2):143-50.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NZ7205000 CHEMICAL NAME : Karminomycin hydrochloride CAS REGISTRY NUMBER : 52794-97-5 LAST UPDATED : 199512 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C26-H27-N-O10.Cl-H MOLECULAR WEIGHT : 550.00 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 23000 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 860 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7200 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Blood - leukopenia Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3400 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Blood - leukopenia Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 3000 ug/kg TOXIC EFFECTS : Blood - changes in bone marrow (not otherwise specified) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1000 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 12000 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 3000 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 400 ng/plate REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8,797,1986

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