34097-16-0

• 常用中文名：氯可托龙特戊酸酯
• 常用英文名：clocortolone pivalate
• CAS号：34097-16-0
• 分子式：C₂₇H₃₆ClFO₅
• 分子量：495.023
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-09-04 16:46:08
• 更新时间：2024-01-07 20:26:15
• 新戊酸氯可托酮是一种合成的糖皮质激素和皮质类固醇酯。新戊酸氯考托隆适用于脂溢性皮炎、接触性皮炎、特应性皮炎和银屑病[1]。

名称

• 中文名: 氯可托龙
• 英文名: clocortolone pivalate
• 英文别名: (6α,11β,16α)-9-chloro-6-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl 2,2-dimethylpropanoate; 9-Chloro-6a-fluoro-11b,21-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione 21-Pivalate; Pregna-1,4-diene-3,20-dione, 9-chloro-21-(2,2-dimethyl-1-oxopropoxy)-6-fluoro-11-hydroxy-16-methyl-, (6α,11β,16α)-; Purantix; (6α,11β,16α)-9-Chloro-6-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl pivalate; CLODERM; CL 68; (6a,11b,16a)-9-Chloro-21-(2,2-dimethyl-1-oxopropoxy)-6-fluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione; clocortolone pivalate; Clocortolone 21-pivalate; 9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-pivalate; SH-863; Propanoic acid, 2,2-dimethyl-, (6α,11β,16α)-9-chloro-6-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl ester; Clocortolone triMethylacetate; 9α-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-pivalate

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 598.0±50.0 °C at 760 mmHg
• 分子式: C₂₇H₃₆ClFO₅
• 分子量: 495.023
• 闪点: 315.4±30.1 °C
• 精确质量: 494.223541
• PSA: 80.67000
• LogP: 4.36
• 蒸汽压: 0.0±3.8 mmHg at 25°C
• 折射率: 1.552
• 储存条件: 2-8°C

生物活性

• 描述: 新戊酸氯可托酮是一种合成的糖皮质激素和皮质类固醇酯。新戊酸氯考托隆适用于脂溢性皮炎、接触性皮炎、特应性皮炎和银屑病[1]。
• 相关类别:
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Kircik LH, et al. The treatment of inflammatory facial dermatoses with topical corticosteroids: focus on clocortolone pivalate 0.1% cream. J Drugs Dermatol. 2012 Oct;11(10):1194-8.

安全

• 危险品运输编码: NONH for all modes of transport