毒理学数据:
1、急性毒性:
大鼠经口LD50:1840mg/kg;
大鼠吸入LC5O:11063mg/m3/6H;
小鼠经口LD50:3720mg/kg;
小鼠吸入LC5O:6203mg/m3/6H;
小鼠经腹腔膜LD:>500 mg/kg;
兔子皮肤LD50:2800mg/kg
生态学数据:
对水稍有危害。
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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TH1130000
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CHEMICAL NAME :
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Phosphorous acid, triethyl ester
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CAS REGISTRY NUMBER :
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122-52-1
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BEILSTEIN REFERENCE NO. :
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0956578
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LAST UPDATED :
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199701
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DATA ITEMS CITED :
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12
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MOLECULAR FORMULA :
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C6-H15-O3-P
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MOLECULAR WEIGHT :
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166.18
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,218,1992
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,218,1992
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Mammal - species unspecified
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REFERENCE :
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MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 29,393,1978
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Mammal - species unspecified
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REFERENCE :
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MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 29,393,1978 ** ACUTE TOXICITY DATA **
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1840 mg/kg
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TOXIC EFFECTS :
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Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
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REFERENCE :
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ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,218,1992
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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11063 mg/m3/6H
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes Gastrointestinal - changes in structure or function of salivary glands
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REFERENCE :
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ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,218,1992
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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3720 mg/kg
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TOXIC EFFECTS :
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Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
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REFERENCE :
-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,218,1992
-
TYPE OF TEST :
-
LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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6203 mg/m3/6H
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes Gastrointestinal - changes in structure or function of salivary glands
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REFERENCE :
-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,218,1992
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>500 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 5,286,1953
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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2800 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,218,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84307 No. of Facilities: 38 (estimated) No. of Industries: 3 No. of Occupations: 18 No. of Employees: 5414 (estimated)
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