217500-96-4

• 常用中文名：托拉菌素 A
• 常用英文名：Tulathromycin A
• CAS号：217500-96-4
• 分子式：C₄₁H₇₉N₃O₁₂
• 分子量：806.079
• 相关类别： 原料药 抗生素类药物 其它抗生素类药
• 发布时间：2018-04-24 08:00:00
• 更新时间：2024-01-02 17:25:48
• Tulathromycin A 是大环内酯类抗生素，MIC90为1μg/ml。

名称

• 中文名: 托拉菌素 A
• 英文名: Tulathromycin A
• 中文别名: 土拉霉素A; 土拉霉素 A; 泰拉霉素A; 托拉菌素A; 泰拉霉素
• 英文别名: (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-Dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-a-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one; Tulathromycin; Draxxin; Unii-897A3kn7ap

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 853.8±65.0 °C at 760 mmHg
• 分子式: C₄₁H₇₉N₃O₁₂
• 分子量: 806.079
• 闪点: 470.2±34.3 °C
• 精确质量: 805.566345
• PSA: 200.90000
• LogP: 4.07
• 外观性状: 粉末
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.536
• 储存条件: -20℃

生物活性

• 描述: Tulathromycin A 是大环内酯类抗生素,MIC90为1μg/ml。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Villarino N, et al. Pharmacokinetics of tulathromycin in healthy and neutropenic mice challenged intranasally withlipopolysaccharide from Escherichia coli. Antimicrob Agents Chemother. 2012 Aug;56(8):4078-4086.

  [2]. Godinho KS, et al. Efficacy of tulathromycin in the treatment of bovine respiratory disease associated with induced Mycoplasma bovis infections in young dairy calves. Vet Ther. 2005 Summer;6(2):96-112.

  [3]. Godinho KS, et al. Minimum inhibitory concentrations of tulathromycin against respiratory bacterial pathogens isolated from clinical cases in European cattle and swine and variability arising from changes in in vitro methodology. Vet Ther. 2005 Summer;6(2

  [4]. Rooney KA, et al. Efficacy of tulathromycin compared with tilmicosin and florfenicol for the control of respiratory disease in cattle at high risk of developing bovine respiratory disease. Vet Ther. 2005 Summer;6(2):154-66.

  [5]. Kilgore WR, et al. Therapeutic efficacy of tulathromycin, a novel triamilide antimicrobial, against bovine respiratory disease in feeder calves. Vet Ther. 2005 Summer;6(2):143-53.