10045-52-0

• 常用中文名：1-(2-苯基-1,3-噻唑-4-基)乙酮
• 常用英文名：1-(2-Phenyl-1,3-thiazol-4-yl)ethan-1-one
• CAS号：10045-52-0
• 分子式：C₁₁H₉NOS
• 分子量：203.26000
• 发布时间：2018-12-27 17:15:54
• 更新时间：2025-09-10 09:22:32

名称

• 中文名: 1-(2-苯基-1,3-噻唑-4-基)乙酮
• 英文名: 1-(2-phenyl-1,3-thiazol-4-yl)ethanone
• 中文别名: 1-(2-苯基-1,3-噻唑-4-基)-1-乙酮
• 英文别名: 1-(2-phenylthiazol-4-yl)ethanone; 5-Acetyl-2-phenylthiohydantoinsaeure; 4-Acetyl-2-phenylthiazole; 1-(2-Phenylthiazol-4-yl)ethanone; 2-Phenyl-4-acetylthiazol; 4-acetyl-2-phenyl-1,3-thiazole; 1-(2-Phenyl-1,3-thiazol-4-yl)ethan-1-one

物化性质

• 密度: 1.203g/cm3
• 沸点: 353.5ºC at 760mmHg
• 熔点: 84ºC
• 分子式: C₁₁H₉NOS
• 分子量: 203.26000
• 闪点: 167.6ºC
• 精确质量: 203.04000
• PSA: 58.20000
• LogP: 3.01270
• 蒸汽压: 3.58E-05mmHg at 25°C
• 折射率: 1.594

MSDS

Name: 1-(2-Phenyl-1 3-thiazol-4-yl)ethan-1-one 97% Material Safety Data Sheet Synonym: 4-Acetyl-2-phenylthiazol CAS: 10045-52-0 Section 1 - Chemical Product MSDS Name:1-(2-Phenyl-1 3-thiazol-4-yl)ethan-1-one 97% Material Safety Data Sheet Synonym:4-Acetyl-2-phenylthiazol Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 10045-52-0 1-(2-Phenyl-1,3-thiazol-4-yl)ethan-1-o 97% unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Not available. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. May be harmful if inhaled. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 10045-52-0: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: brown Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 88 - 90 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C11H9NOS Molecular Weight: 203 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Oxidizing agents, bases, amines. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 10045-52-0 unlisted. LD50/LC50: Not available. Carcinogenicity: 1-(2-Phenyl-1,3-thiazol-4-yl)ethan-1-one - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 10045-52-0: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 10045-52-0 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 10045-52-0 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi: Irritant;
• 安全声明 (欧洲): S24/25
• 海关编码: 2934100090

合成路线

1001669-22-2 75-16-1 ~97% 10045-52-0

文献：BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C. Patent: WO2013/163279 A1, 2013 ; Location in patent: Paragraph 00219 ;

68158-17-8 ~86% 10045-52-0

文献：Sarodnick; Kempter Pharmazie, 1983 , vol. 38, # 12 p. 829 - 832

186581-53-3 20949-81-9 ~51% 10045-52-0

文献：Shafiee, A.; Anaraki, M.; Bazzaz, A. Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 861 - 864

57372-14-2 ~% 10045-52-0

文献：Chemische Berichte, , vol. 97, p. 1915 - 1920

2227-79-4 ~% 10045-52-0

文献：Chemische Berichte, , vol. 97, p. 1915 - 1920

7113-10-2 ~% 10045-52-0

文献：WO2013/163279 A1, ;

59937-01-8 ~% 10045-52-0

文献：WO2013/163279 A1, ;

36094-04-9 ~% 10045-52-0

文献：WO2013/163279 A1, ;

上下游产品

上游产品  10
1001669-22-2 75-16-1 68158-17-8 186581-53-3
20949-81-9 57372-14-2 2227-79-4 7113-10-2
59937-01-8 36094-04-9
下游产品  2
7113-10-2 57372-14-2

海关

海关编码	2934100090
中文概述	2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%