中文名 | 4-氨基-5-氯-2-甲氧基苯甲酸 |
---|---|
英文名 | 4-Amino-5-chloro-2-methoxybenzoic acid |
中文别名 |
4-氨基-5-氯邻茴香酸
4-氨基-5-氯-邻茴香酸 |
英文别名 |
MFCD00038794
4-amino-5-chloro-2-methoxybenzoic acid EINECS 230-582-3 |
密度 | 1.438 g/cm3 |
---|---|
沸点 | 369.7ºC at 760 mmHg |
熔点 | 206-210ºC |
分子式 | C8H8ClNO3 |
分子量 | 201.60700 |
闪点 | 177.4ºC |
精确质量 | 201.01900 |
PSA | 72.55000 |
LogP | 2.21020 |
外观性状 | 白色至略米色粉末 |
储存条件 | 密封于阴凉干燥处。 |
稳定性 | 遵照规格使用和储存则不会分解。 |
分子结构 | 1、 摩尔折射率:48.99 2、 摩尔体积(m3/mol):140.1 3、 等张比容(90.2K):387.7 4、 表面张力(dyne/cm):58.5 5、 极化率(10-24cm3):19.42 |
计算化学 | 1.疏水参数计算参考值(XlogP):无 2.氢键供体数量:2 3.氢键受体数量:4 4.可旋转化学键数量:2 5.互变异构体数量:3 6.拓扑分子极性表面积72.6 7.重原子数量:13 8.表面电荷:0 9.复杂度:200 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1 |
更多 | 1. 性状:无色液体。 2. 密度(g/mL,25/4℃): 0.973 3. 相对蒸汽密度(g/mL,空气=1):6.9 4. 熔点(ºC):15 5. 沸点(ºC,常压):150-152 6. 沸点(ºC,5.2kPa): 无可用 7. 折射率: 1.502 8. 闪点(ºC): 无可用 9. 比旋光度(º):无可用 10. 自燃点或引燃温度(ºC):162 11. 蒸气压(kPa,25ºC):无可用 12. 饱和蒸气压(kPa,60ºC):无可用 13. 燃烧热(KJ/mol):无可用 14. 临界温度(ºC):无可用 15. 临界压力(KPa):无可用 16. 油水(辛醇/水)分配系数的对数值:无可用 17. 爆炸上限(%,V/V):无可用 18. 爆炸下限(%,V/V): 无可用 19. 溶解性:能溶于水 |
Synonym:None known Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 22 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Harmful if swallowed.The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 7206-70-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: white Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 205.00 - 208.00 deg C Autoignition Temperature: 530 deg C ( 986.00 deg F) Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: > 206 deg C Solubility in water: 90 MG/L (20C) Specific Gravity/Density: Molecular Formula: C8H8ClNO3 Molecular Weight: 201.61 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, excess heat, strong oxidants. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 7206-70-4 unlisted. LD50/LC50: Not available. Carcinogenicity: 4-Amino-5-Chloro-2-Methoxybenzoic Acid - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 22 Harmful if swallowed. Safety Phrases: S 28A After contact with skin, wash immediately with plenty of water. S 28B After contact with skin, wash immediately with plenty of water and soap. S 37 Wear suitable gloves. S 38 In case of insufficient ventilation, wear suitable respiratory equipment. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 7206-70-4: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 7206-70-4 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 7206-70-4 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
生态学数据: 该物质对环境可能有危害,对水体应给予特别注意。
|
符号 |
GHS07 |
---|---|
信号词 | Warning |
危害声明 | H315-H319-H335 |
警示性声明 | P261-P305 + P351 + P338 |
个人防护装备 | dust mask type N95 (US);Eyeshields;Gloves |
危害码 (欧洲) | Xn:Harmful; |
风险声明 (欧洲) | R22 |
安全声明 (欧洲) | S28-S38 |
危险品运输编码 | NONH for all modes of transport |
WGK德国 | 3 |
海关编码 | 2922509090 |
~83% 7206-70-4 |
文献:Anphar, S.A. Patent: US4138492 A1, 1979 ; |
~% 7206-70-4 |
文献:WO2005/23808 A2, ; Page/Page column 37-38 ; |
~87% 7206-70-4 |
文献:Ehrenkaufer, Richard L.; Scripko, James G.; Hoffman, Patricia L. Organic Preparations and Procedures International, 1992 , vol. 24, # 1 p. 64 - 66 |
~% 7206-70-4 |
文献:Organic Preparations and Procedures International, , vol. 24, # 1 p. 64 - 66 |
~% 7206-70-4 |
文献:Letters in Drug Design and Discovery, , vol. 9, # 5 p. 489 - 493 |
~% 7206-70-4 |
文献:Letters in Drug Design and Discovery, , vol. 9, # 5 p. 489 - 493 |
~% 7206-70-4 |
文献:Letters in Drug Design and Discovery, , vol. 9, # 5 p. 489 - 493 |
~% 7206-70-4 |
文献:Letters in Drug Design and Discovery, , vol. 9, # 5 p. 489 - 493 |
上游产品 8 | |
---|---|
下游产品 10 | |
海关编码 | 2922509090 |
---|---|
中文概述 | 2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB. 最惠国关税:6.5%. 普通关税:30.0% |
申报要素 | 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装 |
监管条件 | A.入境货物通关单 B.出境货物通关单 |
检验检疫 | R.进口食品卫生监督检验 S.出口食品卫生监督检验 |
Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |