71301-82-1

• 常用中文名：(S)-3-羟基苯甘氨酸
• 常用英文名：oxfenicine
• CAS号：71301-82-1
• 分子式：C₈H₉NO₃
• 分子量：167.162
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 谷氨酸受体
• 发布时间：2018-09-13 08:45:28
• 更新时间：2024-01-09 13:21:35
• (S) -3-羟基苯基甘氨酸((S)-3HPG)是一种有效的mGluR1激动剂,对mGlu2或mGlu4[1]没有作用。

名称

• 中文名: (S)-3-羟基苯基甘氨酸
• 英文名: (s)-3-hydroxyphenylglycine
• 英文别名: (2S)-Amino(3-hydroxyphenyl)acetic acid; (S)-amino-(3-hydroxyphenyl)acetic acid; (2S)-(+)-2-(3-Hydroxyphenyl)glycin; (+)-o-fluorophenylglycine; Benzeneacetic acid, α-amino-3-hydroxy-, (αS)-; oxfenicine; 2-(2-FLUOROPHENYL)GLYCINE; (aS)-a-Amino-4-hydroxybenzeneacetic Acid; Benzeneacetic acid, α-amino-4-hydroxy-, (αS)-; (2S)-amino(3-hydroxyphenyl)ethanoic acid; (S)-2-(3-Hydroxyphenyl)glycine; (2S)-Amino(4-hydroxyphenyl)acetic acid; (S)-a-Amino-4-hydroxybenzeneacetic Acid; (S)-AMINO-(2-FLUORO-PHENYL)-ACETIC ACID; Pyrrolidinedithiocarbamate ammonium; S-3-hydroxyphenylglycine; (S)-2-amino-2-(2-fluorophenyl)acetic acid; (2S)-amino(4-hydroxyphenyl)ethanoic acid

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 382.6±32.0 °C at 760 mmHg
• 分子式: C₈H₉NO₃
• 分子量: 167.162
• 闪点: 185.2±25.1 °C
• 精确质量: 167.058243
• PSA: 83.55000
• LogP: 0.20
• 外观性状: 固体
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.633
• 储存条件: 2-8°C， 密封， 干燥

生物活性

• 描述: (S) -3-羟基苯基甘氨酸((S)-3HPG)是一种有效的mGluR1激动剂,对mGlu2或mGlu4[1]没有作用。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Y Hayashi, et al. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. J Neurosci. 1994 May;14(5 Pt 2):3370-7.

  [2]. Birse EF, et al. Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience. 1993 Feb;52(3):481-8.

合成路线

899799-15-6 ~95% 71301-82-1

文献：Ku, Hui-Young; Jung, Junyang; Kim, Soo-Hyun; Kim, Hee Yeon; Ahn, Kyo Han; Kim, Sung-Gon Tetrahedron Asymmetry, 2006 , vol. 17, # 7 p. 1111 - 1115

108647-55-8 ~69% 71301-82-1

文献：Weinges, Klaus; Reinel, Ute; Maurer, Wolfgang; Gaessler, Norbert Liebigs Annalen der Chemie, 1987 , p. 833 - 838

114774-44-6 ~% 71301-82-1

文献：Ku, Hui-Young; Jung, Junyang; Kim, Soo-Hyun; Kim, Hee Yeon; Ahn, Kyo Han; Kim, Sung-Gon Tetrahedron Asymmetry, 2006 , vol. 17, # 7 p. 1111 - 1115

899799-11-2 ~% 71301-82-1

文献：Ku, Hui-Young; Jung, Junyang; Kim, Soo-Hyun; Kim, Hee Yeon; Ahn, Kyo Han; Kim, Sung-Gon Tetrahedron Asymmetry, 2006 , vol. 17, # 7 p. 1111 - 1115

899799-13-4 ~% 71301-82-1

文献：Ku, Hui-Young; Jung, Junyang; Kim, Soo-Hyun; Kim, Hee Yeon; Ahn, Kyo Han; Kim, Sung-Gon Tetrahedron Asymmetry, 2006 , vol. 17, # 7 p. 1111 - 1115

621-37-4 ~% 71301-82-1

文献：Ku, Hui-Young; Jung, Junyang; Kim, Soo-Hyun; Kim, Hee Yeon; Ahn, Kyo Han; Kim, Sung-Gon Tetrahedron Asymmetry, 2006 , vol. 17, # 7 p. 1111 - 1115

615553-57-6 ~% 71301-82-1

文献：Arnusch, Christopher J.; Pieters, Roland J. European Journal of Organic Chemistry, 2003 , # 16 p. 3131 - 3138

108594-41-8 ~% 71301-82-1

文献：Weinges, Klaus; Reinel, Ute; Maurer, Wolfgang; Gaessler, Norbert Liebigs Annalen der Chemie, 1987 , p. 833 - 838

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