374791-02-3

• 常用中文名：(R)-1-(((9H-芴-9-基)甲氧基)羰基)氮杂环丁烷-2-羧酸
• 常用英文名：(R)-N-Fmoc-Azetidine-2-Carboxylic Acid
• CAS号：374791-02-3
• 分子式：C₁₉H₁₇NO₄
• 分子量：323.343
• 发布时间：2018-12-20 19:31:26
• 更新时间：2025-08-24 14:58:17

名称

• 中文名: (R)-N-FMOC-吖啶-2-羧酸
• 英文名: (2R)-1-(9H-fluoren-9-ylmethoxycarbonyl)azetidine-2-carboxylic acid
• 中文别名: (R)-N-芴甲氧羰基-吖丁啶-2-羧酸; (R)-1-Fmoc-2-吖丁啶甲酸
• 英文别名: fmoc-d-azetidine-2-carboxylic acid; (2R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-azetidinecarboxylic acid; 1,2-Azetidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester, (2R)-; (R)-N-Fmoc-Azetidine-2-Carboxylic Acid

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 543.3±43.0 °C at 760 mmHg
• 熔点: 139.4ºC
• 分子式: C₁₉H₁₇NO₄
• 分子量: 323.343
• 闪点: 282.3±28.2 °C
• 精确质量: 323.115753
• PSA: 66.84000
• LogP: 2.74
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.651
• 储存条件:

  密闭于阴凉干燥环境中

• 稳定性:

  遵照规定使用和储存则不会分解。

• 分子结构:

  1、摩尔折射率：无可用

  2、 摩尔体积（cm³/mol）：无可用

  3、 等张比容（90.2K）：无可用

  4、 表面张力（dyne/cm）：无可用

  5、 极化率：无可用

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：2.7

  2、 氢键供体数量：3

  3、 氢键受体数量：4

  4、 可旋转化学键数量：2

  5、 拓扑分子极性表面积（TPSA）：89.9

  6、 重原子数量：23

  7、 表面电荷：0

  8、 复杂度：475

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：0

  11、 不确定原子立构中心数量：2

  12、 确定化学键立构中心数量：0

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：1

• 更多:

  1. 性状：无可用

  2. 密度（g/mL,25/4℃）：无可用

  3. 相对蒸汽密度（g/mL,空气=1）：无可用

  4. 熔点（ºC）：无可用

  5. 沸点（ºC,常压）：无可用

  6. 沸点（ºC,5.2kPa）：无可用

  7. 折射率：无可用

  8. 闪点（ºC）：无可用

  9. 比旋光度（º）：无可用

  10. 自燃点或引燃温度（ºC）：无可用

  11. 蒸气压（kPa,25ºC）：无可用

  12. 饱和蒸气压（kPa,60ºC）：无可用

  13. 燃烧热（KJ/mol）：无可用

  14. 临界温度（ºC）：无可用

  15. 临界压力（KPa）：无可用

  16. 油水（辛醇/水）分配系数的对数值：无可用

  17. 爆炸上限（%,V/V）：无可用

  18. 爆炸下限（%,V/V）：无可用

  19. 溶解性：无可用

MSDS

Name: (R)-N-FMOC-Azetidine-2-carboxylic acid 95% (98% e.e.) Material Safety Data Sheet Synonym: (R)-N-(9-Fluorenylmethoxycarbonyl)azetidine-2-carboxylic acid; 1,2-Azetidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester, (2R)- CAS: 374791-02-3 Section 1 - Chemical Product MSDS Name:(R)-N-FMOC-Azetidine-2-carboxylic acid 95% (98% e.e.) Material Safety Data Sheet Synonym:(R)-N-(9-Fluorenylmethoxycarbonyl)azetidine-2-carboxylic acid; 1,2-Azetidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester, (2R)- Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 374791-02-3 (R)-N-FMOC-Azetidine-2-carboxylic acid 95 unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid. Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse. Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid breathing dust. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 374791-02-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 139.4 deg C Autoignition Temperature: Not available. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C19H17NO4 Molecular Weight: 323.34 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Dust generation. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 374791-02-3 unlisted. LD50/LC50: Not available. Carcinogenicity: (R)-N-FMOC-Azetidine-2-carboxylic acid - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 374791-02-3: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 374791-02-3 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 374791-02-3 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 该物质对环境可能有危害，对水体应给予特别注意。

安全

• 危害码 (欧洲): Xi
• 安全声明 (欧洲): S24/25