31690-09-2

• 常用中文名：L-5-甲基四氢叶酸-13C,d3
• 常用英文名：Levomefolic acid
• CAS号：31690-09-2
• 分子式：C₂₀H₂₅N₇O₆
• 分子量：459.456
• 相关类别： 原料药 维生素类与矿物质类药 维生素C类药
• 发布时间：2018-08-11 11:42:53
• 更新时间：2025-08-28 00:43:03
• Levomefolic acid (5-MTHF)是天然的叶酸活性形式。

名称

• 中文名: L-5-甲基四氢叶酸
• 英文名: (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid
• 中文别名: 左美福酸
• 英文别名: N-(5-methyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid; N-[4-({[(6S)-2-Amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]-L-glutamic acid; L-glutamic acid, N-[4-[[[(6S)-1,2,5,6,7,8-hexahydro-4-hydroxy-2-imino-5-methyl-6-pteridinyl]methyl]amino]benzoyl]-; L-5-methyltetrahydrofolic acid; (6S)-5-Methyltetrahydrofolic acid; 5-Methyl-(6S)-tetrahydrofolic acid; 5-Methyltetrahydrofolate; L-5-Methyltetrahydrofolate; Levomefolic acid; Levomefolic Acid (See also L375720); N-[4-({[(6S)-2-Amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid; L-Glutamic acid, N-[4-[[[(6S)-2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-; 5-methyltetrahydrofolic acid; levomefolinic acid; (2S)-2-{[4-({[(6S)-2-Amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]amino}pentanedioic acid

物化性质

• 密度: 1.6±0.1 g/cm3
• 分子式: C₂₀H₂₅N₇O₆
• 分子量: 459.456
• 精确质量: 459.186646
• PSA: 202.77000
• LogP: -2.61
• 折射率: 1.733
• 储存条件: 2-8℃，密封，干燥，对空气敏感

生物活性

• 描述: Levomefolic acid (5-MTHF)是天然的叶酸活性形式。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 叶酸
  研究领域 >> 癌症
• 参考文献:

  [1]. Hirsch S, Miranda D, Mu?oz E, et al. Natural killer cell cytotoxicity is not regulated by folic acid in vitro. Nutrition. 2013 Jan 9. pii: S0899-9007(12)00404-2.

  [2]. Liu Y, Green TJ, Wong P, Kitts DD. Microencapsulation of L-5-methyltetrahydrofolic Acid with ascorbate improves stability in baked bread products. J Agric Food Chem. 2013 Jan 9;61(1):247-54.

  [3]. Merola N, Alonso FJ, Ros G, Castón MJ. Antioxidant activity comparison between [6S]-5-methyltetrahydrofolic acid calcium salt and the related racemate form. Food Chem. 2013 Jan 15;136(2):984-8.

  [4]. Liu Y, Tomiuk S, Rozoy E, et al. Thermal oxidation studies on reduced folate, L-5-methyltetrahydrofolic acid (L-5-MTHF) and strategies for stabilization using food matrices. J Food Sci. 2012 Feb;77(2):C236-43.

  [5]. Bashir M Rezka, Guido R.M.M Haenena, Wim J.F van der Vijgha, et al. Tetrahydrofolate and 5-methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore. 2003,555(3):601-605.

  [6]. Levomefolic acid

合成路线

59-30-3 ~% 31690-09-2

文献：WO2013/25203 A1, ;

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