20537-88-6

• 常用中文名：氨磷汀
• 常用英文名：Amifostine
• CAS号：20537-88-6
• 分子式：C₅H₁₅N₂O₃PS
• 分子量：214.223
• 相关类别： 原料药 专科用药 解毒药
• 发布时间：2018-02-08 08:00:00
• 更新时间：2025-08-20 16:57:56
• 【用途一】
  细胞保护剂，用于化疗对肾、骨髓、心脏的保护
  【用途二】
  化学治疗细胞保护药和放疗保护剂，在放疗或化疗过程中，在杀伤癌细胞时能够选择性地保护正常组织细胞，使患者能连续接受治疗。用于解除抗癌药的肾毒，预防放疗引起的造血系统、免疫损伤等毒副反应有一定的效果，也用于减少和中性白细胞减少症相关的感染。

名称

• 中文名: 氨磷汀
• 英文名: amifostine
• 中文别名: 安磷汀; S-2-[3-氨丙基胺]乙基硫代磷酸
• 英文别名: MFCD00233058; Ethanethiol, 2-[(3-aminopropyl)amino]-, dihydrogen phosphate (ester); Amifostine; Apaetp; 2-(3-aminopropylamino)ethylsulfanylphosphonic acid; Ethyol; WR 2721; Sapep; dihydrogène thiophosphate de S-{2-[(3-aminopropyl)amino]éthyle}; S-{2-[(3-Aminopropyl)amino]ethyl}dihydrogen-thiophosphat; Aminopropylaminoethyl thiophosphate; S-{2-[(3-Aminopropyl)amino]ethyl} dihydrogen phosphorothioate; Ethiofos; Gammaphos

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 441.7±51.0 °C at 760 mmHg
• 熔点: 160-161ºC
• 分子式: C₅H₁₅N₂O₃PS
• 分子量: 214.223
• 闪点: 220.9±30.4 °C
• 精确质量: 214.054092
• PSA: 130.69000
• LogP: -1.68
• 外观性状: 白色固体
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.555
• 储存条件: 库房通风低温干燥
• 计算化学:

  1.疏水参数计算参考值（XlogP）:-4.5

  2.氢键供体数量:4

  3.氢键受体数量:6

  4.可旋转化学键数量:7

  5.互变异构体数量:无

  6.拓扑分子极性表面积121

  7.重原子数量:12

  8.表面电荷:0

  9.复杂度:152

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1.性状：白色固体

  2.熔点：160~161

  3.溶解性：易溶于水

生物活性

• 描述: Amifostine是一种广谱的细胞保护剂,可以抵抗电离辐射和化疗药物对DNA的破坏作用。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. Kouvaris, J.R., V.E. Kouloulias, and L.J. Vlahos, Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist, 2007. 12(6): p. 738-47.

毒性和生态

毒理学数据: 腹腔-大鼠LD50: 418 毫克/公斤; 口服-小鼠LD50: 842毫克/公斤 CHEMICAL IDENTIFICATION RTECS NUMBER : TE6491000 CHEMICAL NAME : Phosphorothioic acid, S-(2-(3-aminopropylamino)ethyl) ester CAS REGISTRY NUMBER : 20537-88-6 LAST UPDATED : 199801 DATA ITEMS CITED : 24 MOLECULAR FORMULA : C5-H15-N2-O3-P-S MOLECULAR WEIGHT : 214.25 WISWESSER LINE NOTATION : Z3M2SPQQO HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 11 mg/kg TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in calcium TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 826 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 418 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 396 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 842 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 321 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 557 mg/kg TOXIC EFFECTS : Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 514 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 279 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Nutritional and Gross Metabolic - body temperature decrease TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 635 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 407 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 21 gm/kg/5W-I TOXIC EFFECTS : Cardiac - pulse rate Vascular - BP lowering not characterized in autonomic section Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 300 mg/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 50 mg/kg SEX/DURATION : female 11 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 550 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 300 mg/kg SEX/DURATION : female 17-22 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 1350 mg/kg SEX/DURATION : female 17-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 1300 mg/kg SEX/DURATION : female 17-22 day(s) after conception lactating female 7 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 1100 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 650 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 65 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - body wall TYPE OF TEST : Micronucleus test MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 300 mg/kg REFERENCE : CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year: 54,1080,1985

安全

• 危害码 (欧洲): Xn:Harmful
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): S26-S36
• WGK德国: 3
• RTECS号: TE6491000
• 海关编码: 2930909090

合成路线

23545-42-8 ~92% 20537-88-6

文献：Laduranty, Joelle; Lion, Claude; Mesnard, Daniele; Miginiac, Leone Bulletin des Societes Chimiques Belges, 1984 , vol. 93, # 10 p. 903 - 912

23545-33-7 ~% 20537-88-6

文献：Bulletin des Societes Chimiques Belges, , vol. 93, # 10 p. 903 - 912

23545-38-2 ~% 20537-88-6

文献：Bulletin des Societes Chimiques Belges, , vol. 93, # 10 p. 903 - 912

上下游产品

上游产品  1
23545-42-8
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制备

【方法一】
方法1：丙二胺和环氧乙烷反应，生成N-羟乙基丙二胺，再和40%的氢溴酸作用，生成N-(2-溴乙基)丙二胺的二氢溴酸盐，最后和硫代磷酸钠的10水合物反应，得到氨磷汀的一水合物。
方法2：化合物(Ⅰ)和化合物(Ⅱ)反应，生成物(Ⅲ)以氢溴酸-乙酸作用，转化为化合物(Ⅳ)和化合物(V)，接着和(Ⅵ)反应，即得氨磷汀。

海关

海关编码	2922499990
中文概述	2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%