53251-94-8

• 常用中文名：匹维溴铵
• 常用英文名：L-Pinaverium bromide
• CAS号：53251-94-8
• 分子式：C₂₆H₄₁Br₂NO₄
• 分子量：591.416
• 相关类别： 原料药 Anesthetic Agents 骨骼肌松弛药
• 发布时间：2018-08-12 18:32:31
• 更新时间：2024-01-04 12:24:34
• Pinaverium bromide 是一种对胃肠道具有选择性的L型 钙通道 阻滞剂,能有效缓解疼痛、腹泻和肠道不适,对肠易激综合征 (IBS) 患者有良好的治疗效果,且无不良反应。

名称

• 中文名: 匹维溴胺
• 英文名: 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethyl-4-bicyclo[3.1.1]heptanyl)ethoxy]ethyl]morpholin-4-ium,bromide
• 中文别名: 4-[(2-溴-4,5-二甲氧基苯基)甲基]-4-[2-[2-(7,7-二甲基-2-双环[3.1.1]庚烷基)乙氧基]乙基]吗啉-4-翁溴化物; 匹维溴铵
• 英文别名: 4-(6-Bromoveratryl)-4-[2-[2-(6,6-dimethyl-2-norpinyl)ethoxy]ethyl]morpholinium Bromide; LAT 1717; Dicetel; EINECS 258-450-0; Pinaverium bromide; UNII-7SCF54H12J; Morpholinium, 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]-, bromide (1:1); 4-(2-Bromo-4,5-dimethoxybenzyl)-4-{2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl}morpholin-4-ium bromide; 4-[(2-Bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]morpholinium Bromide

物化性质

• 熔点: 159-164ºC
• 分子式: C₂₆H₄₁Br₂NO₄
• 分子量: 591.416
• 精确质量: 589.140198
• PSA: 36.92000
• LogP: 2.25510
• 外观性状: 固体;White to Light yellow powder to crystal
• 储存条件: -20°C Freezer

生物活性

• 描述: Pinaverium bromide 是一种对胃肠道具有选择性的L型 钙通道 阻滞剂,能有效缓解疼痛、腹泻和肠道不适,对肠易激综合征 (IBS) 患者有良好的治疗效果,且无不良反应。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 其他
• 靶点:

  Calcium channel[1].

• 参考文献:

  [1]. Dai Y, et al. Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats. World J Gastroenterol. 2003 Mar;9(3):557-61.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QF2810000 CHEMICAL NAME : Morpholinium, 4-(2-bromo-4,5-dimethoxy)benzyl-4-(2-(2-(6,6-dimethyl -2-norpinyl)ethoxy) ethyl)-, bromide CAS REGISTRY NUMBER : 53251-94-8 LAST UPDATED : 199109 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C26-H41-Br-N-O4.Br MOLECULAR WEIGHT : 591.50 WISWESSER LINE NOTATION : L46 ATJ A1 A1 E2O2- AT6K DOTJ A1R BE DO1 EO1 &E &24/47 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 504 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 40,133,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 37 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,182,1974

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