57-74-9

• 常用中文名：氯丹
• 常用英文名：chlordane
• CAS号：57-74-9
• 分子式：C₁₀H₆Cl₈
• 分子量：409.779
• 相关类别： 化学农药原药 杀虫剂 有机氯杀虫剂
• 发布时间：2018-07-09 12:41:19
• 更新时间：2026-07-01 21:52:11

• 环戊二烯类含氯杀虫剂，用于杀灭地下害虫，如蝼蛄、地老虎、稻草害虫等，对防治白蚁效果显著。

名称

• 中文名: 氯丹
• 英文名: chlordane
• 中文别名: 氯丹农药溶液(基体:异辛烷); 八氯-六氯-甲撑茚; CD68(抗原); 皮带,带状物; 环己烷中氯丹; 人参皂苷CK(标准品); 1,2,4,5,6,7,8,8-八氯-2,3,3a,4 ,7,7a-六氢-亚甲桥茚(八氯化茚); 1,2,4,5,6,7,8,8-八氯-3A,4,7,7A-四氢-4,7-甲撑茚满; 八氯化茚; 氯丹/SH/混合物; 惟洗可; 氯丹农药溶液; CD68抗原; 1,2,4,5,6,7,8,8-八氯-2,3,3Α,4,7,7Α-六氢-4,7-甲撑茚; 异辛烷中工业氯丹农药溶液; 1,2,4,5,6,7,8,8-八氯-2,3,3a,4,7,7a-六氢-4,7-亚甲基茚; 氯旦; 正己烷中氯丹; CD68分子; 丙酮中氯丹标准溶液; 八氯化甲桥茚; 工业氯丹; gamma-氯丹
• 英文别名: 1,2,4,5,6,7,8,8-OCTACHLORO-4,7-METHANE-3A,4,7,7A-TETRAHYDROINDANE; 1,2,4,5,6,7,8,8-OCTACHLORO-2,3,3A,4,7,7A-HEXAHYDRO-4,7-METHANOINDANE; CHLORDANE, 1X1ML, MEOH, 20UG/ML; GP110; ANTI-CD68/CD68 (KPI) (CENTER) antibody produced in rabbit; chloordaan; CHLORDANE,M, NEAT; OCTACHLOR(R); CHLORDANE; 1,2,4,5,6,7,8,8-octa-8,8-octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindan; chlordane (bsi,iso,esa,esa,jmaf); SCD1; CHLORDANE REFERENCE STANDD FOR A METHODS 508, 608, 625; CD-68(R); 1,2,4,5,6,7,8,8-OCTACHLORO-4,7-METHANO-3 A,4,7,7A-TETRAHYDROINDANE; Octachlor; 1,2,4,5,6,7,8,8-Ottochloro-3a,4,7,7a-tetraidro-4,7-endo-metano-indano; 1,2,4,5,6,7,8,8-ottochloro-3a,4,7,7a-tetrahydro-4,7-endo-methano-indaan(dutch; TERMSEAL; 4,7-Methanoindan, 1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro; CHLORDANE, 1X1ML, MEOH, 500UG/ML; chlordane (ISO) 1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindan; TERMISEAL; Belt; Chlordan; 1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetra-hydro-4,7-methan; 1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methanoindene; 1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene; 1068 Steral; Chlor kill; 'L'; 1-Exo,2-endo,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methanoindene; Chlordance; TERMIDAN; MAHATZ; (1Ξ,2Ξ,3aΞ,4Ξ,7Ξ,7aΞ)-1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene; 1,2,4,5,6,7,8,8-OCTACHLORO-4,7-METHANO-3ALPHA,4,7,7ALPHA-TETRAHYDROINDANE; TERMEX; Recombinant Human CD68; 1,2,4,5,6,7,8,8-OCTACHLORO-3A,4,7,7A-TETRAHYDRO-4,7-METHANOINDENE; DKFZp686M18236; Chlordane, alpha & gamma isomers; 4,7-methanoindan,1,2,4,5,6,7,8,8,-octachloro-2,3,3a,4,7,7a-hexahydro; EINECS 200-349-0; 1,2,4,5,6,7,8,8-octahydro-2,3,3a,4,7,7a-hexahydro-4,7-methanoindan; alpha-, gamma-Chlordane; Chlordane (alpha and gamma isomers); CHLORDITE; 3a,4,7,7a-Tetrahydro-1,2,4,5,6,7,8,8-chloro-4,7-methanoindane; VELSICOL 1068(R); CHLORDRITE; 1-exo,2-endo-4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane; Chlordane [-9]; CHLORDANE, 1X10ML, ISO, 200UG/ML; chlordane (mixture of isomers); OCTA-KLOR(R); 4,7-Methano-1H-indene,1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro; Chlor Kil; Aspon-chlordane; TOXICHLOR(R)

物化性质

• 密度: 1.8±0.1 g/cm3
• 沸点: 424.7±40.0 °C at 760 mmHg
• 熔点: 106 - 107ºC
• 分子式: C₁₀H₆Cl₈
• 分子量: 409.779
• 闪点: 212.5±24.7 °C
• 精确质量: 405.797760
• LogP: 5.57
• 外观性状: 灰白色粉末
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.627
• 储存条件:

  库房通风低温干燥; 与氧化剂、食品添加剂分开存放

• 稳定性:

  琥珀色粘稠液体。沸点175℃。不溶于水，溶于有机溶剂。相对密度1.59-1.63（25/4℃），折光率nD251.56-1.57。在碱性溶液中易分解失去杀虫力。可燃； 燃烧产生有毒氯化物烟雾

• 分子结构:

  五、分子性质数据：

  1、 摩尔折射率：80.27

  2、 摩尔体积（cm³/mol）：226.4

  3、 等张比容（90.2K）：614.2

  4、 表面张力（dyne/cm）：54.1

  5、 介电常数（F/m）：

  6、 偶极距（D）：

  7、 极化率（10^-24cm³）：31.82

MSDS

第一部分：化学品名称 化学品中文名称: 氯丹,M-410 化学品英文名称: Chlordane,Octachlor CAS No.: 57-74-9 分子式: C10H6Cl8 分子量: 409.78 第二部分：成分/组成信息 化学品名称：氯丹,M-410 有害物成分: 氯丹 含量: 无资料 CAS No.: 57-74-9 第三部分：危险性概述 侵入途径: 无资料 健康危害: 急性中毒：中毒症状发生较快，几小时内即可能死亡。主要症状为中枢神经系统兴奋症状，如激动、震颤、全身抽搐；摄入中毒的症状出现更快，有恶心、呕吐、全身抽搐。严重中毒在抽搐剧烈和反复发作后陷于木僵、昏迷和呼吸衰竭。慢性中毒：主要症状为神经系统的功能性紊乱，肝、肾退行性改变。有头痛、眼球痛、全身乏力、失眠、恶梦、头晕、心前区不适、四肢麻木和酸痛等。 环境危害: 对环境有严重危害，对水体、土壤和大气可造成污染。 燃爆危险: 本品不燃，有毒。 第四部分：急救措施 皮肤接触: 无资料 眼睛接触: 提起眼睑，用流动清水或生理盐水冲洗。就医。 吸入: 迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。 食入: 饮足量温水，催吐。洗胃，导泄。就医。 第五部分：消防措施 危险特性: 一般不会燃烧, 但长时间暴露在明火及高温下仍能燃烧。受高热分解产生有毒的腐蚀性烟气。 有害燃烧产物: 一氧化碳、二氧化碳、氯化氢。 灭火方法及灭火剂: 本品不燃。尽可能将容器从火场移至空旷处。喷水保持火场容器冷却，直至灭火结束。迅速切断气源，然后根据着火原因选择适当灭火剂灭火。 消防员的个体防护: 消防人员须佩戴防毒面具、穿全身消防服 禁止使用的灭火剂: 无资料 闪点(℃): 无资料 自燃温度(℃): 无资料 爆炸下限[%(V/V)]: 无资料 爆炸上限[%(V/V)]: 无资料 第六部分：泄漏应急处理 应急处理: 迅速撤离泄漏污染区人员至安全区，并进行隔离，严格限制出入。建议应急处理人员戴自给正压式呼吸器，穿防毒服。尽可能切断泄漏源。小量泄漏：用砂土或其它不燃材料吸附或吸收。也可以用不燃性分散剂制成的乳液刷洗，洗液稀释后放入废水系统。大量泄漏：构筑围堤或挖坑收容。用泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。 第七部分：操作处置与储存 操作注意事项: 密闭操作，提供充分的局部排风。操作尽可能机械化、自动化。操作人员必须经过专门培训，严格遵守操作规程。建议操作人员佩戴过滤式防毒面具（半面罩），戴化学安全防护眼镜，穿防毒物渗透工作服，戴乳胶手套。防止蒸气泄漏到工作场所空气中。避免与氧化剂接触。搬运时要轻装轻卸，防止包装及容器损坏。配备泄漏应急处理设备。倒空的容器可能残留有害物。 储存注意事项: 储存于阴凉、通风的库房。远离火种、热源。应与氧化剂、食用化学品分开存放，切忌混储。储区应备有泄漏应急处理设备和合适的收容材料。 第八部分：接触控制/个体防护 最高容许浓度: 中国MAC:未制定标准；前苏联MAC：未制定标准 ；美国TWA：ACGIH 0.5mg/m3[皮],TLVWN： ACGIH 2mg/m3[皮] 监测方法: 无资料 工程控制: 严加密闭，提供充分的局部排风。尽可能机械化、自动化。提供安全淋浴和洗眼设备。 呼吸系统防护: 空气中浓度较高时，应该佩戴过滤式防毒面具（半面罩）。紧急事态抢救或逃生时，建议佩戴空气呼吸器。 眼睛防护: 戴化学安全防护眼镜 身体防护: 穿防毒物渗透工作服。 手防护: 戴乳胶手套。 第九部分：理化特性 外观与性状: 无色或淡黄色液体，工业品为有杉木气味的琥珀色液体。 熔点(℃): 无资料 沸点(℃): 175/0.27kPa 相对密度(水=1): 1.61 相对蒸气密度(空气=1): 无资料 饱和蒸气压(kPa): 0.27/175℃ 闪点(℃): 无资料 引燃温度(℃): 无资料 爆炸上限%(V/V): 无资料 爆炸下限%(V/V): 无资料 分子式: C10H6Cl8 分子量: 409.78 溶解性: 不溶于水，溶于多数有机溶剂。 主要用途: 用作残留性杀虫剂。 第十部分：稳定性和反应活性 稳定性: 在常温常压下 禁配物: 无资料 避免接触的条件: 无资料 聚合危害: 无资料 分解产物: 无资料 第十一部分：毒理学资料 急性毒性: LD50：200 mg/kg(大鼠经口)；145 mg/kg(小鼠经口) LC50：100mg/m3，4小时(猫吸入) 急性中毒: 无资料 慢性中毒: 无资料 刺激性: 无资料 第十二部分：生态学资料 生态毒理毒性: 无资料 生物降解性: 无资料 非生物降解性: 无资料 第十三部分：废弃处置 废弃物性质: 无资料 废弃处置方法: 根据国家和地方有关法规的要求处置。或与厂商或制造商联系，确定处置方法。 废弃注意事项: 无资料 第十四部分：运输信息 危险货物编号: 61877 UN编号: 2762 包装方法: 小开口钢桶；螺纹口玻璃瓶、塑料瓶、复合塑料瓶或铝瓶外普通木箱。 运输注意事项: 运输前应先检查包装容器是否完整、密封，运输过程中要确保容器不泄漏、不倒塌、不坠落、不损坏。严禁与酸类、氧化剂、食品及食品添加剂混运。运输时运输车辆应配备泄漏应急处理设备。运输途中应防曝晒、雨淋，防高温。公路运输时要按规定路线行驶，勿在居民区和人口稠密区停留。 第十五部分：法规信息 国内化学品安全管理法规: 运输前应先检查包装容器是否完整、密封，运输过程中要确保容器不泄漏、不倒塌、不坠落、不损坏。严禁与酸类、氧化剂、食品及食品添加剂混运。运输时运输车辆应配备泄漏应急处理设备。运输途中应防曝晒、雨淋，防高温。公路运输时要按规定路线行驶，勿在居民区和人口稠密区停留。 第十六部分：其他信息 填表时间: 2004年12月9日 填表部门: 无资料 数据审核单位: 无资料 修改说明: 无资料 MSDS修改日期: 1900年1月1日

毒性和生态

毒理学数据: 口服- 大鼠 LD50: 200 毫克/ 公斤; 口服- 小鼠 LD50: 145 毫克/ 公斤 CHEMICAL IDENTIFICATION RTECS NUMBER : PB9800000 CHEMICAL NAME : 4,7-Methanoindan, 1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro- CAS REGISTRY NUMBER : 57-74-9 LAST UPDATED : 199712 DATA ITEMS CITED : 88 MOLECULAR FORMULA : C10-H6-Cl8 MOLECULAR WEIGHT : 409.76 WISWESSER LINE NOTATION : L C555 A IUTJ AG AG BG DG EG HG IG JG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 3071 ug/kg TOXIC EFFECTS : Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 29 mg/kg TOXIC EFFECTS : Liver - fatty liver degeneration TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 120 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Gastrointestinal - gastritis TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Human DOSE/DURATION : 428 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - man DOSE/DURATION : 118 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 690 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 343 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 145 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 240 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 100 mg/m3/4H TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - excitement TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 780 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 1720 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - chicken DOSE/DURATION : 220 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - duck DOSE/DURATION : 1200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - domestic DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : >20 gm/m3/4H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 410 mg/kg/39W-C TOXIC EFFECTS : Liver - other changes TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 28200 ug/m3/8H/28D-I TOXIC EFFECTS : Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 660 mg/kg/15D-I TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6512 mg/kg/58W-I TOXIC EFFECTS : Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5475 mg/kg/2Y-C TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), zonal Liver - changes in liver weight Related to Chronic Data - death TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10 mg/m3/8H/90D-I TOXIC EFFECTS : Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - changes in calcium TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 504 mg/kg/12W-C TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2020 mg/kg/80W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3780 mg/kg/80W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 3360 ug/kg SEX/DURATION : female 1-21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Effects on Newborn - biochemical and metabolic TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 152 mg/kg SEX/DURATION : female 1-19 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - immune and reticuloendothelial system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 7 mg/kg SEX/DURATION : female 15-21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - behavioral TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 3040 ug/kg SEX/DURATION : female 1-19 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - biochemical and metabolic TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 168 mg/kg SEX/DURATION : female 1-21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - delayed effects TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 168 mg/kg SEX/DURATION : female 1-21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - immune and reticuloendothelial system TYPE OF TEST : Sister chromatid exchange TYPE OF TEST : Morphological transformation TYPE OF TEST : Mutation test systems - not otherwise specified TYPE OF TEST : Cytogenetic analysis MUTATION DATA TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - hamster Lung REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 19,369,1977 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,45,1979 IARC Cancer Review:Animal Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,146,1987 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,115,1991 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,45,1979 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,115,1991 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,115,1991 TOXICOLOGY REVIEW CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966- Volume(issue)/page/year: 10(3),43,1975 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 56,107,1975 TOXICOLOGY REVIEW BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925- Volume(issue)/page/year: 54,413,1978 TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 13,231,1978 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 0.5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,44,1971 OSHA PEL (Gen Indu):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.5 mg/m3;Skin JAN 1993 OEL-AUSTRALIA:TWA 0.5 mg/m3;STEL 2 mg/m3;Skin;Carcinogen JAN 1993 OEL-AUSTRIA:TWA 0.5 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.5 mg/m3;STEL 2 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.5 mg/m3;Skin;Carcinogen JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.5 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 0.5 mg/m3;Skin;Carcinogen JAN 1993 OEL-INDIA:TWA 0.5 mg/m3;STEL 2 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.5 mg/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 mg/m3;Skin JAN 1993 OEL-RUSSIA:STEL 0.01 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.5 mg/m3;Skin JAN 1993 OEL-THAILAND:TWA 0.5 mg/m3 JAN 1993 OEL-TURKEY:TWA 0.5 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 2 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CHLORDANE-air:10H CA TWA 0.5 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

安全

• 符号: GHS06, GHS08
• 信号词: Danger
• 危害声明: H301 + H311 + H331-H370
• 警示性声明: P260-P280-P301 + P310-P311
• 个人防护装备: Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
• 危害码 (欧洲): F;T
• 风险声明 (欧洲): 21/22-40-50/53-36/37/38-11-39/23/24/25-23/24/25
• 安全声明 (欧洲): 36/37-60-61-36-33-26-16-45-7
• 危险品运输编码: 2995
• RTECS号: PB9800000
• 包装等级: II
• 危险类别: 6.1(b)

合成路线

3734-48-3 ~% 57-74-9

文献：Chemische Berichte, , vol. 99, p. 421 - 430

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环戊二烯用氯气氯化，在40-60℃得到四氯环戊烷，进一步加热、通氯，得到多氯环戊烷，将其在汽化釜中气化后与氯气在500-560℃氯解得到六氯环戊二烯。六氯环戊二烯在55℃左右与环戊二烯反应生成氯啶，然后在80℃左右通氯，就得到氯丹。