2622-26-6

• 常用中文名：氰噻嗪
• 常用英文名：Periciazine
• CAS号：2622-26-6
• 分子式：C₂₁H₂₃N₃OS
• 分子量：365.492
• 发布时间：2018-07-12 21:46:52
• 更新时间：2024-01-05 07:09:24
• Pericyazine (Propericiazine) 是第一代抗精神病药物,被用作短期管理严重焦虑状态和精神病的辅助药物。Pericyazine (Propericiazine) 是一种选择性的 D2 多巴胺受体 (D2-dopamine receptor) 拮抗剂。

名称

• 中文名: 氰噻嗪
• 英文名: periciazine
• 中文别名: 哌氰嗪
• 英文别名: Neuleptil; 2-Cyano-10-[3-(4-hydroxypiperidino)propyl]phenothiazine; Nemactil; 10-[3-(4-Hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile; propericyazine; 10H-Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxy-1-piperidinyl)propyl]-; Aolept; properciazine; Propericiazine; Periciazine; Piperocyanomazine; 10-[3-(4-Hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile; Pericyazine; Neulactil; Periciazina; Periciazinum; 10-<3-(4-hydroxypiperidino)propyl>phenothiazine-2-carbonitrile; 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 593.4±50.0 °C at 760 mmHg
• 分子式: C₂₁H₂₃N₃OS
• 分子量: 365.492
• 闪点: 312.7±30.1 °C
• 精确质量: 365.156189
• PSA: 75.80000
• LogP: 3.76
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.694
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: Pericyazine (Propericiazine) 是第一代抗精神病药物,被用作短期管理严重焦虑状态和精神病的辅助药物。Pericyazine (Propericiazine) 是一种选择性的 D2 多巴胺受体 (D2-dopamine receptor) 拮抗剂。
• 靶点:

  D2-dopamine receptor[2]

• 参考文献:

  [1]. Morley KC, et al. Pericyazine in the treatment of cannabis dependence in general practice: a naturalistic pilot trial. Subst Abuse Rehabil. 2012 May 28;3:43-7.

  [2]. Farde L, et al. D1- and D2-dopamine receptor occupancy during treatment with conventional and atypicalneuroleptics. Psychopharmacology (Berl). 1989;99 Suppl:S28-31.

  [3]. Divac N, et al. Second-generation antipsychotics and extrapyramidal adverse effects. Biomed Res Int. 2014;2014:656370.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SN7175000 CHEMICAL NAME : Phenothiazine-2-carbonitrile, 10-(3-(4-hydroxypiperidino)propyl)- CAS REGISTRY NUMBER : 2622-26-6 LAST UPDATED : 199612 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C21-H23-N3-O-S MOLECULAR WEIGHT : 365.53 WISWESSER LINE NOTATION : T C666 BN ISJ ECN B3- AT6NTJ DQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 395 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 85 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,43,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,43,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 35 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,43,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 530 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 157,1242,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 115 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 157,1242,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 375 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 157,1242,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 27700 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,74,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 1,203,1974

安全

• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R22
• 海关编码: 2934300000

海关

海关编码	2934300000
中文概述	2934300000. 含一个吩噻嗪环系的化合物(吩噻嗪环系不论是否氢化,化合物未经进一步稠合的 ). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%