毒理学数据:
口服- 大鼠 LD50: 1600 毫克/ 公斤; 吸入- 大鼠 LC50: 101 ppm/6小时。
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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AS7000000
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CHEMICAL NAME :
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Acrylic acid, 2-cyano-, methyl ester
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CAS REGISTRY NUMBER :
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137-05-3
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BEILSTEIN REFERENCE NO. :
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1751282
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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28
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MOLECULAR FORMULA :
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C5-H5-N-O2
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MOLECULAR WEIGHT :
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111.11
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WISWESSER LINE NOTATION :
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1UYCN&VO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Human
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1600 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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101 ppm/6H
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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>10959 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intratesticular
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DOSE :
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100 mg/kg
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SEX/DURATION :
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male 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
MUTATION DATA
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TYPE OF TEST :
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Mutation in microorganisms
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TEST SYSTEM :
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Bacteria - Salmonella typhimurium
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REFERENCE :
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MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 188,97,1987 *** REVIEWS *** ACGIH TLV-STEL 18 mg/m3 (4 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 9.1 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 2 ppm (8 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,162,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (8 mg/m3);STEL 4 ppm (16 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 2 ppm (8 mg/m3) JAN 1993 OEL-BELGIUM:TWA 2 ppm (9.1 mg/m3);STEL 4 ppm (18 mg/m3) JAN 1993 OEL-DENMARK:TWA 2 ppm (8 mg/m3) JAN 1993 OEL-FINLAND:TWA 2 ppm (9 mg/m3);STEL 4 ppm (18 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 2 ppm (8 mg/m3);STEL 4 ppm (16 mg/m3) JAN 1993 OEL-GERMANY:TWA 2 ppm (8 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (8 mg/m3) JAN 1993 OEL-SWEDEN:TWA 2 ppm (9 mg/m3);STEL 4 ppm (18 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (9 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (8 mg/m3);STEL 4 ppm (16 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL 2-CYANOACRYLATE-air:10H TWA 2 ppm;STEL 4 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4755 No. of Facilities: 895 (estimated) No. of Industries: 25 No. of Occupations: 25 No. of Employees: 18406 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4755 No. of Facilities: 1434 (estimated) No. of Industries: 46 No. of Occupations: 51 No. of Employees: 51367 (estimated) No. of Female Employees: 22918 (estimated)
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