304-81-4

304-81-4结构式

常用中文名：叶枯净
常用英文名：Phenazine, 5-oxide
CAS号：304-81-4
分子式：C₁₂H₈N₂O
分子量：196.20500
相关类别：化学农药原药杀菌剂其他杀菌剂
发布时间：2018-07-20 12:29:57
更新时间：2024-01-10 16:52:42
该品是以保护作用为主的防治水稻白叶枯病的专用杀菌剂，也可与防治稻瘟病等药剂混用，进行综合防治。

中文名	叶枯净
英文名	phenazine oxide
中文别名	杀枯净夹二氮蒽-5-氧化物 5-氧吩嗪
英文别名	phenasine-5-oxide phenazine mono-N-oxide Phenazin phenazine 5-oxide Phenazin-5-oxid Phenazine 9-oxide 5-oxidophenazin-5-ium Phenazine monooxide N-Oxyphenazine Phenazine-N-oxide phenazine-N5-oxide Phenazin-5-oxide N-Oxide de phenazine

密度	1.28g/cm3
沸点	404.3ºC at 760mmHg
熔点	226.5°C
分子式	C₁₂H₈N₂O
分子量	196.20500
闪点	198.3ºC
精确质量	196.06400
PSA	38.35000
LogP	2.81650
折射率	1.683
储存条件	库房通风低温干燥; 与食品原料分开储运
稳定性	金黄色针状结晶。熔点226.5℃，难溶于水，微溶于甲醇、乙醇、乙醚及芒烃类，易溶于氯仿、苯、二甲苯和硝基苯。在碱性介质中稳定，在浓度大于15%的盐酸溶液中形杨盐酸盐，但在稀酸或水中又水解成5-氧吩嗪。化学性质稳定。
分子结构	1、摩尔折射率：58.06 2、摩尔体积（cm³/mol）：153.0 3、等张比容（90.2K）：412.8 4、表面张力（dyne/cm）：52.9 5、极化率（10^-24cm³）：23.01
计算化学	1.疏水参数计算参考值（XlogP）:1.6 2.氢键供体数量:0 3.氢键受体数量:2 4.可旋转化学键数量:0 5.互变异构体数量:无 6.拓扑分子极性表面积38.4 7.重原子数量:15 8.表面电荷:0 9.复杂度:212 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1

毒理学数据:

口服- 大鼠 LD50: 6600 毫克/公斤; 口服- 小鼠 LD50: 5500 毫克/ 公斤

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SG1590000

CHEMICAL NAME :: Phenazine, 5-oxide

CAS REGISTRY NUMBER :: 304-81-4

BEILSTEIN REFERENCE NO. :: 0150977

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C12-H8-N2-O

MOLECULAR WEIGHT :: 196.22

WISWESSER LINE NOTATION :: T C666 BN INJ BO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6600 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5500 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 87500 mg/kg/2Y-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10080 mg/kg/96W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 201 mg/kg

SEX/DURATION :: female 91 day(s) pre-mating - 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 201 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 mg/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 116,185,1983

海关编码	2933990019

74497-02-2

304-81-4

文献：Chemische Berichte, , vol. 36, p. 4135 Chemische Berichte, , vol. 34, p. 2444 Anm. 2

1484-35-1

304-81-4

119-75-5

文献：Heterocycles, , vol. 33, # 2 p. 573 - 584

2217-65-4

304-81-4

文献：Collection of Czechoslovak Chemical Communications, , vol. 48, # 2 p. 379 - 393

92-82-0

304-81-4

文献：Journal of Chemical Thermodynamics, , vol. 23, # 1 p. 31 - 36

1484-35-1

304-81-4

文献：Heterocycles, , vol. 33, # 2 p. 573 - 584

110-82-7

303-83-3

304-81-4

108-94-1

详细

文献：Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 39, # 5 p. 886 - 890 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 5 p. 994 - 999

98-95-3

74497-02-2

92-82-0

304-81-4

详细

文献：Chemische Berichte, , vol. 36, p. 4135 Chemische Berichte, , vol. 34, p. 2444 Anm. 2

92-82-0

~50%

304-81-4

303-83-3

文献：Bulletin des Societes Chimiques Belges, , vol. 99, # 10 p. 783 - 788

上游产品 6
92-82-0 1484-35-1 2217-65-4 110-82-7
303-83-3 98-95-3
下游产品 8
105837-00-1 92-82-0 3577-37-5 1137-69-5
3442-62-4 2876-23-5 2876-33-7 2876-34-8

海关编码	2933990019
中文概述	2933990019 多效唑,烯效唑,抑芽唑等〔包括异麦赛津,叶枯净,叶锈特,吡喃草酮,吲哚乙酸〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
监管条件	S.进出口农药登记证明
Summary	2933990019 phenazine 5-oxide。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

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