116680-01-4

• 常用中文名：Mycophenolate mofetil hydrochloride
• 常用英文名：Mycophenolate mofetil hydrochloride
• CAS号：116680-01-4
• 分子式：C₂₃H₃₂ClNO₇
• 分子量：469.96
• 相关类别： 研究领域 癌症
• 发布时间：2017-03-26 01:50:37
• 更新时间：2026-07-01 21:13:31
• 霉酚酸酯(RS 61443)盐酸盐是一种免疫抑制剂,是一种I/II型肌苷单磷酸脱氢酶(IMPD)的非竞争性、选择性和可逆抑制剂,IC50s分别为39 nM和27 nM。

名称

• 英文名: 2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate,hydrochloride
• 英文别名: Rs 61; Mycophenolate Mofetil Hydrochloride API; Cellct; 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, hydrochloride, (4E); 2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methyl-hex-4-enoate hydrochloride; Unii-uxh81S8zvb; Mycophenolate mofetil HCl; Mycophenolate Mofetil Hydrochloride D4Q: What is Mycophenolate Mofetil Hydrochloride D4 Q: What is the CAS Number of Mycophenolate Mofetil Hydrochloride D4 Q: What is the storage condition of Mycophenolate Mofetil Hydrochloride D4 Q: What e the applications of Mycophenolate Mofetil Hydrochloride D4; 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, hydrochloride, (E)

物化性质

• 密度: 1.222g/cm3
• 沸点: 637.6ºC at 760mmHg
• 分子式: C₂₃H₃₂ClNO₇
• 分子量: 469.96
• 闪点: 339.4ºC
• 精确质量: 469.18700
• PSA: 94.53000
• LogP: 3.26390
• 蒸汽压: 7.51E-17mmHg at 25°C
• 折射率: 1.557
• 储存条件: 2-8°C，干燥，密封

生物活性

• 描述: 霉酚酸酯(RS 61443)盐酸盐是一种免疫抑制剂,是一种I/II型肌苷单磷酸脱氢酶(IMPD)的非竞争性、选择性和可逆抑制剂,IC50s分别为39 nM和27 nM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 靶点:

  Human Endogenous Metabolite

• 参考文献:

  [1]. Nakanishi, T., et al., Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection. Int Immunopharmacol, 2010. 10(1): p. 91-7.

  [2]. Dehghani, F., et al., Inhibition of microglial and astrocytic inflammatory responses by the immunosuppressant mycophenolate mofetil. Neuropathol Appl Neurobiol, 2010. 36(7): p. 598-611.

  [3]. Ozgen, M., et al., Mycophenolate mofetil and daclizumab targeting T lymphocytes in bleomycin-induced experimental scleroderma. Clin Exp Dermatol, 2012. 37(1): p. 48-54.

安全

• 危害码 (欧洲): Xi

合成路线

622-40-2 111512-13-1 ~% 116680-01-4

文献：SANDOZ AG Patent: WO2005/23791 A2, 2005 ; Location in patent: Page/Page column 14 ;

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