114776-28-2

• 常用中文名：贝帕泛
• 常用英文名：Bepafant
• CAS号：114776-28-2
• 分子式：C₂₃H₂₂ClN₅O₂S
• 分子量：467.97100
• 发布时间：2018-06-26 18:08:05
• 更新时间：2024-04-06 10:13:45
• Bepafant, also known as WEB-2170 and STY-2108, is a platelet activating factor (PAF) antagonist potentially for the treatment of asthma. Bepafant triggered apoptosis in NB4, KG1, and NB4-MR4 cells where PTEN was expressed, but not in THP1 and U937 cells where PTEN was absent. Bepafant may produce significant anti-inflammatory effects.

名称

• 中文名: 贝帕泛
• 英文名: Bepafant
• 英文别名: 6-(2-chlorophenyl)-8,9-dihydro-1-methyl-8-[(4-morpholinyl)carbonyl]-4H,7H-cyclopenta-[4,5]thieno-[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine; Web 2170; 4-((6-(o-chlorophenyl)-8,9-dihydro-1-methyl-4h,7h-cyclopenta[4,5]thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepin-8-yl)carbonyl)morpholine; Bepafanto [INN-Spanish]

物化性质

• 密度: 1.59g/cm3
• 沸点: 744.5ºC at 760mmHg
• 分子式: C₂₃H₂₂ClN₅O₂S
• 分子量: 467.97100
• 闪点: 404.1ºC
• 精确质量: 467.11800
• PSA: 100.85000
• LogP: 2.58870
• 蒸汽压: 4.86E-22mmHg at 25°C
• 折射率: 1.792