36703-88-5

• 常用中文名：异丙肌苷
• 常用英文名：Isoprinosine
• CAS号：36703-88-5
• 分子式：C₅₂H₇₈N₁₀O₁₇
• 分子量：1115.23
• 相关类别： 原料药 影响免疫功能药 免疫调节药
• 发布时间：2018-02-21 08:00:00
• 更新时间：2024-01-02 16:37:29
• Inosine pranobex 是一种用于 HIV 感染的有效广谱抗病毒化合物。Inosine pranobex 是一种免疫增强剂。

名称

• 中文名: 异丙肌苷
• 英文名: Isoprinosine
• 中文别名: 异丙肌肝
• 英文别名: Inosine, compd. with 1-(dimethylamino)-2-propanol 4-(acetylamino)benzoate (salt) (1:3); 4-acetamidobenzoic acid,9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one,1-(dimethylamino)propan-2-ol

物化性质

• 沸点: 732.8ºC at 760 mmHg
• 分子式: C₅₂H₇₈N₁₀O₁₇
• 分子量: 1115.23
• 闪点: 397ºC
• 精确质量: 1114.554688
• PSA: 403.10000
• LogP: 1.76610
• 外观性状: 固体;White to Almost white powder to crystal
• 储存条件: 存放于惰性气体之中;避免湿气 (吸湿)
• 稳定性:

  本品是肌苷和与二甲氨基异丙醇、对乙酰氨苯甲酸酯的复合物，为微黄色或无色粉末，微苦，易吸湿，可溶于水。

• 水溶解性: 水溶性：完全溶解；可溶于：乙醇,甲醇；不溶：乙醚
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:13

  3.氢键受体数量:21

  4.可旋转化学键数量:14

  5.互变异构体数量:252

  6.拓扑分子极性表面积399

  7.重原子数量:79

  8.表面电荷:0

  9.复杂度:658

  10.同位素原子数量:0

  11.确定原子立构中心数量:4

  12.不确定原子立构中心数量:3

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:7

生物活性

• 描述: Inosine pranobex 是一种用于 HIV 感染的有效广谱抗病毒化合物。Inosine pranobex 是一种免疫增强剂。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 参考文献:

  [1]. Renoux G, et al. Isoprinosine as an immunopotentiator. J Immunopharmacol. 1979;1(3):337-56.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NM7461240 CAS REGISTRY NUMBER : 36703-88-5 LAST UPDATED : 199109 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C10-H12-N4-O5.3C9-H9-N-O3.3C5-H13-N-O HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 9150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,906,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2960 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,124,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3460 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,906,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1970 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,906,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9410 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,906,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,124,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2960 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,906,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1570 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,906,1988