873079-69-7

• 常用中文名：AX 048
• 常用英文名：AX 048
• CAS号：873079-69-7
• 分子式：C₂₂H₄₁NO₄
• 分子量：383.565
• 发布时间：2016-01-11 04:15:52
• 更新时间：2024-01-20 11:48:29
• AX-048is a potent group IVA cPLA2 inhibitor. The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes.

名称

• 英文名: ethyl 4-(2-oxohexadecanoylamino)butanoate
• 英文别名: Butanoic acid, 4-[(1,2-dioxohexadecyl)amino]-, ethyl ester; unii-8782z45dlv; ax 048; Ethyl 4-[(2-oxohexadecanoyl)amino]butanoate

物化性质

• 密度: 1.0±0.1 g/cm3
• 分子式: C₂₂H₄₁NO₄
• 分子量: 383.565
• 精确质量: 383.303558
• PSA: 72.47000
• LogP: 6.81
• 折射率: 1.462
• 储存条件: -20°C，密闭，干燥

合成路线

764-67-0 ~% 873079-69-7

文献：Yaksh, Tony L.; Kokotos, George; Svensson, Camilla I.; Stephens, Daren; Kokotos, Christoforos G.; Fitzsimmons, Bethany; Hadjipavlou-Litina, Dimitra; Hua, Xiao-Ying; Dennis, Edward A. Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 316, # 1 p. 466 - 475

5959-36-4 ~% 873079-69-7

文献：Yaksh, Tony L.; Kokotos, George; Svensson, Camilla I.; Stephens, Daren; Kokotos, Christoforos G.; Fitzsimmons, Bethany; Hadjipavlou-Litina, Dimitra; Hua, Xiao-Ying; Dennis, Edward A. Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 316, # 1 p. 466 - 475

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