Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release

…, B Fitzsimmons, D Hadjipavlou-Litina, XY Hua…

文献索引：Yaksh, Tony L.; Kokotos, George; Svensson, Camilla I.; Stephens, Daren; Kokotos, Christoforos G.; Fitzsimmons, Bethany; Hadjipavlou-Litina, Dimitra; Hua, Xiao-Ying; Dennis, Edward A. Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 316, # 1 p. 466 - 475

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被引用次数: 63

摘要

Abstract Phospholipase A 2 (PLA 2) forms are expressed in spinal cord, and inhibiting spinal PLA 2 induces a potent antihyperalgesia. Here, we examined the antihyperalgesic effects after systemic and it delivery of four compounds constructed with a common motif consisting of a 2-oxoamide with a hydrocarbon tail and a four-carbon tether. These molecules were characterized for their ability to block group IVA calcium-dependent PLA 2 (cPLA 2) and ...