Abstract Phospholipase A 2 (PLA 2) forms are expressed in spinal cord, and inhibiting spinal PLA 2 induces a potent antihyperalgesia. Here, we examined the antihyperalgesic effects after systemic and it delivery of four compounds constructed with a common motif consisting of a 2-oxoamide with a hydrocarbon tail and a four-carbon tether. These molecules were characterized for their ability to block group IVA calcium-dependent PLA 2 (cPLA 2) and ...
