1225-65-6

• 常用中文名：异THIPENDYL
• 常用英文名：(dimethyl)[10H-pyrido[3,2-b][1,4]benzothiazine-10-propyl]ammonium chloride
• CAS号：1225-65-6
• 分子式：C₁₆H₂₀ClN₃S
• 分子量：321.86800
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-05-22 08:00:00
• 更新时间：2024-02-08 11:34:14
• Prothipendyl hydrochloride 可用于老年人精神症状的研究 (比如焦虑)。

名称

• 中文名: 异THIPENDYL
• 英文名: N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-1-amine,hydrochloride
• 英文别名: (3-Benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-dimethyl-amin,Monohydrochlorid; Dominal hydrochloride; Dominal forte; (dimethyl)(10H-pyrido[3,2-b][1,4]benzothiazine-10-propyl)ammonium chloride; N,N-dimethyl-10H-pyrido[3,2-b][1,4]benzothiazine-10-propanamine,monohydrochloride; 10-(3-Dimethylaminopropyl)-1-azaphenothiazine hydrochloride; Tolnate; Prothipendyl HCl; (3-benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-dimethyl-amine,monohydrochloride; Prothipendyl hydrochloride; Azacon

物化性质

• 分子式: C₁₆H₂₀ClN₃S
• 分子量: 321.86800
• 精确质量: 321.10700
• PSA: 41.43000
• LogP: 1.15470

生物活性

• 描述: Prothipendyl hydrochloride 可用于老年人精神症状的研究 (比如焦虑)。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. J F FLEETWOOD, et al. The Treatment of Mental Symptoms in the Aged With Prothipendyl (Tolnate). J Coll Gen Pract. 1964 Sep;8(2):262-6.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UU8750000 CHEMICAL NAME : 10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(3-(dimethylamino)propyl)-, monohydrochloride CAS REGISTRY NUMBER : 1225-65-6 LAST UPDATED : 199012 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C16-H19-N3-S.Cl-H MOLECULAR WEIGHT : 321.90 WISWESSER LINE NOTATION : T C666 BN DN ISJ B1Y1&N1&1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 610 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 115 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1323 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 110 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972