112344-52-2

• 常用中文名：4-(2',4'-二氟-[1,1'-联苯]-4-基)-2-甲基-4-氧代丁酸
• 常用英文名：4-(2',4'-Difluoro-[1,1'-biphenyl]-4-yl)-2-methyl-4-oxobutanoic acid
• CAS号：112344-52-2
• 分子式：C₁₇H₁₄F₂O₃
• 分子量：304.28800
• 发布时间：2017-03-11 09:11:38
• 更新时间：2024-01-16 13:19:06

名称

• 中文名: 4-(2',4'-二氟-[1,1'-联苯]-4-基)-2-甲基-4-氧代丁酸
• 英文名: 4-[4-(2,4-difluorophenyl)phenyl]-2-methyl-4-oxobutanoic acid
• 英文别名: 4-(2',4'-difluorobipenyl-4-yl)-2-methyl-4-oxobutyric acid; 3-(4-(2,4-Difluorophenyl)benzoyl)-2-methylpropionic acid; 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid; rac-flobufen; [1,1'-Biphenyl]-4-butanoicacid,2',4'-difluoro-a-methyl-g-oxo; 4-(2',4'-Difluorobiphenylyl)-4-oxo-2-methylbutanoic acid; 4-(2',4'-Difluorbiphenyl-4-yl)-2-methyl-4-oxobutansaeure [German]; Flobufen

物化性质

• 密度: 1.272g/cm3
• 沸点: 456.5ºC at 760mmHg
• 分子式: C₁₇H₁₄F₂O₃
• 分子量: 304.28800
• 闪点: 229.9ºC
• 精确质量: 304.09100
• PSA: 54.37000
• LogP: 3.92530
• 外观性状: 固体
• 储存条件: 室温， 密封， 干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DV1758000 CHEMICAL NAME : (1,1'-Biphenyl)-4-butanoic acid, 2',4'-difluoro-alpha-methyl-gamma-oxo- CAS REGISTRY NUMBER : 112344-52-2 LAST UPDATED : 199712 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C17-H14-F2-O3 MOLECULAR WEIGHT : 304.31 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 134 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,24,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 414 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 47,648,1997

安全

• 危害码 (欧洲): Xn

合成路线

161692-81-5 ~76% 112344-52-2

文献：Kuchar, Miroslav; Poppova, Marie; Zunova, Hana; Knezova, Eva; Vosatka, Vaclav; Prihoda, Marek Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 12 p. 2705 - 2713

97-65-4 ~% 112344-52-2

文献：Kuchar, Miroslav; Poppova, Marie; Zunova, Hana; Knezova, Eva; Vosatka, Vaclav; Prihoda, Marek Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 12 p. 2705 - 2713

2170-03-8 ~% 112344-52-2

文献：Kuchar, Miroslav; Poppova, Marie; Zunova, Hana; Knezova, Eva; Vosatka, Vaclav; Prihoda, Marek Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 12 p. 2705 - 2713

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