42281-59-4

• 常用中文名：奥昔啡烷
• 常用英文名：Oxilorphan
• CAS号：42281-59-4
• 分子式：C₂₀H₂₇NO₂
• 分子量：313.43400
• 发布时间：2018-06-09 09:41:08
• 更新时间：2024-02-11 10:43:06

名称

• 中文名: 奥昔啡烷
• 英文名: Oxilorphan
• 英文别名: (L)-BC-2605; Oxilorfano [INN-Spanish]; Levo-BC-2605; Bristol laboratories BC 2605; (-)-17-Cyclopropylmethylmorphinan-3,4-diol; 3,14-dihydroxy-N-cyclopropylmethylmorphinan; EINECS 255-749-8

物化性质

• 密度: 1.27g/cm3
• 沸点: 495.4ºC at 760mmHg
• 分子式: C₂₀H₂₇NO₂
• 分子量: 313.43400
• 闪点: 262.9ºC
• 精确质量: 313.20400
• PSA: 43.70000
• LogP: 2.91340
• 折射率: 1.653

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QC7800000 CHEMICAL NAME : Morphinan-3,14-diol, 17-(cyclopropylmethyl)- CAS REGISTRY NUMBER : 42281-59-4 LAST UPDATED : 199009 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C20-H27-N-O2 MOLECULAR WEIGHT : 313.48 WISWESSER LINE NOTATION : T6 G666/FQ 2AF Q FX ONT&TTJ AQ IQ O1- AL3TJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 14 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - other changes REFERENCE : JCPCBR Journal of Clinical Pharmacology. (Hall Assoc., PO Box 482, Stamford, CT 06904) V.13- 1973- Volume(issue)/page/year: 16,183,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Human DOSE/DURATION : 26 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,746,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 315 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 193,23,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 32 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 193,23,1975