上海化源生化科技有限公司
上海市上海市普陀区
产品名：异丙嗪
纯度：99.0%
规格：
联系人：徐经理
联系电话：133 1186 9306

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：Promethazine
纯度：98.0%
规格：100mg/1g/25mg/500mg
联系人：阿拉丁
联系电话：400-620-6333

广东翁江化学试剂有限公司
广东省韶关市翁源县
产品名：异丙嗪
纯度：95.0%
规格：500g/100g
联系人：朱丽丹
联系电话：13927877242

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60-87-7生产厂家

60-87-7价格

60-87-7

60-87-7结构式

常用中文名：异丙嗪
常用英文名：Promethazine
CAS号：60-87-7
分子式：C₁₇H₂₀N₂S
分子量：284.41900
相关类别：原料药激素及调节内分泌功能类药前列腺素类药
发布时间：2018-07-25 21:25:38
更新时间：2025-08-21 01:37:16

化源商城直购

中文名	异丙嗪
英文名	promethazine
中文别名	菲那根普鲁米近
英文别名	10-[2-(dimethylamino)propyl]phenothiazine Avomine 3277 RP (RS)-dimethyl[1-methyl-2-(phenothiazone-10-yl)ethyl]amine hydrochloride Dimapp PROMETHAZINE WY 509 Procit Fenazil Fargan Prorex Aprobit

密度	1.131
沸点	190-192ºC at 3 mm Hg
熔点	60ºC
分子式	C₁₇H₂₀N₂S
分子量	284.41900
精确质量	284.13500
PSA	31.78000
LogP	4.30440
外观性状	白色固体
折射率	1.6000 (estimate)
储存条件	室温，密闭，干燥

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO6825000

CHEMICAL NAME :: Phenothiazine, 10-(2-dimethylaminopropyl)-

CAS REGISTRY NUMBER :: 60-87-7

BEILSTEIN REFERENCE NO. :: 0088554

LAST UPDATED :: 199707

DATA ITEMS CITED :: 32

MOLECULAR FORMULA :: C17-H20-N2-S

MOLECULAR WEIGHT :: 284.45

WISWESSER LINE NOTATION :: T C666 BN ISJ B1Y1&N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Rinsed with water

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - wakefulness Behavioral - hallucinations, distorted perceptions

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 2857 ug/kg/C

TOXIC EFFECTS :: Behavioral - coma

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 169 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 326 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 124 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 580 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 116 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 520 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 350 mg/kg

SEX/DURATION :: female 10-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 350 mg/kg

SEX/DURATION :: female 4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 mg/L

REFERENCE :: SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949- Volume(issue)/page/year: 70,943,1983 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 1,203,1974 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0709 No. of Facilities: 177 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 886 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0709 No. of Facilities: 49 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1726 (estimated) No. of Female Employees: 1010 (estimated)

海关编码	2934300000

58-33-3

~89%

60-87-7

文献：SOUTHWEST RESEARCH INSTITUTE Patent: WO2003/105811 A2, 2003 ; Location in patent: Page 26 ;

92-84-2

17256-39-2

~70%

60-87-7

文献：Galons; Miocque; Combet-Farnoux; et al. Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 5108 - 5109

92-84-2

53309-35-6

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文献：Journal of the American Chemical Society, , vol. 82, p. 1600 - 1607

60-87-7

7640-51-9

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文献：Transition Metal Chemistry, , vol. 36, # 7 p. 767 - 774

92-84-2

108-14-5

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文献：Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 225, p. 306 US2607773 , ;

38878-40-9

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文献：Journal of Physical Chemistry, , vol. 88, # 23 p. 5665 - 5669

92-84-2

108-14-5

303-14-0

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文献：DE828103 , ; DRP/DRBP Org.Chem. Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 232, p. 415

72332-06-0

92-84-2

303-14-0

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文献：Journal of Organic Chemistry, , vol. 45, # 4 p. 744 - 746

上游产品 8
58-33-3 92-84-2 17256-39-2 53309-35-6
60-87-7 108-14-5 38878-40-9 72332-06-0
下游产品 4
7640-51-9 60-87-7 581-30-6 38076-67-4

海关编码	2934300000
中文概述	2934300000. 含一个吩噻嗪环系的化合物(吩噻嗪环系不论是否氢化,化合物未经进一步稠合的 ). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

60-87-7	73745-50-3
80882-48-0	80882-47-9
1314904-55-6	301681-48-1
949355-11-7	1047663-68-2
22362-63-6	205594-62-3
384348-61-2	1052537-48-0

60-87-7

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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