345891-62-5

• 常用中文名：阿托伐他汀甲酯
• 常用英文名：Atorvastatin methyl ester
• CAS号：345891-62-5
• 分子式：C₃₄H₃₇FN₂O₅
• 分子量：572.66600
• 相关类别： 研究领域 代谢疾病
• 发布时间：2018-09-28 12:25:26
• 更新时间：2026-07-16 19:02:38
• Atorvastatin methyl ester (Compound 2a) 是 Atorvastatin 的甲基酯化衍生物。Atorvastatin methyl ester 比 Atorvastatin 更能抑制 9-顺式-RA 诱导的 Gal4 报告基因活性。

名称

• 中文名: 阿托伐他汀甲酯
• 英文名: methyl (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
• 中文别名: 阿托伐他汀杂质O; (3R,5R)-甲基7-(2-(4-氟苯基)-5-异丙基-3-苯基-4-(苯基氨基甲酰)-1H-吡咯-1-基)-3,5-二羟基庚酸酯; (BET,DELT-2-(4-氟苯基)-BETA,DELTA-二羟基-5-(异丙基)-3-苯基-4-[(苯基氨基)羰基]-1H-吡咯-1-庚酸甲酯; 阿托伐他汀杂质6 CRS(阿托伐他汀杂质K CRS); 阿托伐他汀杂质K; 阿托伐他汀钙杂质J; 阿托伐他汀钙杂质J(阿托伐他汀甲酯); 阿托伐他汀钙杂质K; 阿托伐他汀酸甲酯; 阿托伐他汀杂质6(阿托伐他汀杂质K); 阿托伐他汀钙杂质12; 阿托伐他汀杂质J对照品; 阿伐他汀杂质9; 阿托伐他丁甲酯; (3R,5R)-7-(2-(4-氟苯基)-5-异丙基-3-苯基-4-(苯基氨基甲酰基)-1H-吡咯-1-基)-3,5-二羟基庚酸甲酯; 阿托伐他汀钙杂质J对照品; 阿托伐他汀钙甲酯对照品; 阿托伐他汀杂质IMP-42
• 英文别名: Atorvastatin Calcium Hydrate impurity J; methyl (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyhtanoate; (3R,5R)-Methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcbaMoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyhtanoate; ATV imp K (methyl ester); Atorvastatin Impurity 6 CRS（Atorvastatin Impurity K CRS）; Atorvastatin Acid Methyl Ester (3R,5R)-7-[3-(Phenylcbamoyl)-5-(4-fluorophenyl)-2-isopropyl- 4-phenyl-1H-pyrrol-1-yl]-3,5 -dihydroxyhtanoic acid methyl ester; Atorvastatin Impurity 6（Atorvastatin Impurity K）; 1H-Pyrrole-1-htanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, methyl ester, (βR,δR); Atorvastatin Acid Methyl EsterQ: What is Atorvastatin Acid Methyl Ester Q: What is the CAS Number of Atorvastatin Acid Methyl Ester Q: What is the storage condition of Atorvastatin Acid Methyl Ester Q: What e the applications of Atorvastatin Acid Methyl Ester; Atorvastatin Impurity-K (Methyl ester); Atorvastatin Impurity 6; Atorvastatin calcium impurity 12; (bet,delt-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-htanoic acid methyl ester; atorvastatin methyl ester; Atorvastatin Impurity O; methyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl- 4-(phenylcbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyhtanoate; Atorvastatin Impurity J reference substance; Atorvastatin Impurity K; (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyhtanoate; Atorvastatin impurity 10/Atorvastatin Methyl Ester/Methyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyhtanoate; Atorvastatin calcium-7; Methyl (βR,δR)-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-htanoate; (3R,5R)-Methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcbamoyl)-1H-pyrrol-1-yl)-3,5; (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-htanoic Acid Methyl Ester; Atorvastatin Impurity Methyl Ester; Atorvastatin Calcium Impurity K; Atorvastatin Methyl Ester Impurity; Atorvastatin Impurityeference substance; (3R,5R)-methyl 7-(2-(4-fluorophenyl); Atorvastatin Methyl Ester; Atorvastatin Methyl Impurity; (3R,5R)-7-[3-(Phenylcbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyhtanoic acid methyl ester; Noradrenaline Impurity 70; Methyl (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcbamoyl)-5-(1-methylethyl)-1Hpyrrol- 1-yl]-3,5-dihydroxyhtanoate; methylester of atorvastatin; Atorvastatin Acid Methyl Ester

物化性质

• 分子式: C₃₄H₃₇FN₂O₅
• 分子量: 572.66600
• 精确质量: 572.26900
• PSA: 100.79000
• LogP: 6.47500
• 折射率: 1.653

生物活性

• 描述: Atorvastatin methyl ester (Compound 2a) 是 Atorvastatin 的甲基酯化衍生物。Atorvastatin methyl ester 比 Atorvastatin 更能抑制 9-顺式-RA 诱导的 Gal4 报告基因活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Wang X, et al. Discovery of atorvastatin as a tetramer stabilizer of nuclear receptor RXRα through structure-based virtual screening. Bioorg Chem. 2019 Apr;85:413-419.

安全

• 海关编码: 2933990090

合成路线

1353049-81-6 ~94% 345891-62-5

文献：Chen, Xiaofei; Xiong, Fangjun; Chen, Wenxue; He, Qiuqin; Chen, Fener Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2723 - 2728

67-56-1 134523-00-5 ~% 125995-03-1 345891-62-5

文献：British Journal of Pharmacology, , vol. 132, # 6 p. 1183 - 1192

67-56-1 134523-00-5 ~% 345891-62-5

文献：Stach, Jan; Havlicek, Jaroslav; Placek, Lukas; Radl, Stanislav Collection of Czechoslovak Chemical Communications, 2008 , vol. 73, # 2 p. 229 - 246

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%