Atorvastatin methyl ester

Modify Date: 2024-01-11 19:22:11

Atorvastatin methyl ester Structure
Atorvastatin methyl ester structure
Common Name Atorvastatin methyl ester
CAS Number 345891-62-5 Molecular Weight 572.66600
Density N/A Boiling Point N/A
Molecular Formula C34H37FN2O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Atorvastatin methyl ester


Atorvastatin methyl ester (Compound 2a) is a methyl esterified derivative of Atorvastatin. Atorvastatin methyl ester inhibits the 9-cis-RA-induced Gal4 reporter activity more strongly than Atorvastatin[1].

 Names

Name methyl (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
Synonym More Synonyms

 Atorvastatin methyl ester Biological Activity

Description Atorvastatin methyl ester (Compound 2a) is a methyl esterified derivative of Atorvastatin. Atorvastatin methyl ester inhibits the 9-cis-RA-induced Gal4 reporter activity more strongly than Atorvastatin[1].
Related Catalog
References

[1]. Wang X, et al. Discovery of atorvastatin as a tetramer stabilizer of nuclear receptor RXRα through structure-based virtual screening. Bioorg Chem. 2019 Apr;85:413-419.

 Chemical & Physical Properties

Molecular Formula C34H37FN2O5
Molecular Weight 572.66600
Exact Mass 572.26900
PSA 100.79000
LogP 6.47500
Index of Refraction 1.653

 Safety Information

HS Code 2933990090

 Synthetic Route

~94%

Atorvastatin methyl ester Structure

Atorvastatin me...

CAS#:345891-62-5

Literature: Chen, Xiaofei; Xiong, Fangjun; Chen, Wenxue; He, Qiuqin; Chen, Fener Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2723 - 2728

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Atorvastatin methyl ester Structure

Atorvastatin me...

CAS#:345891-62-5

Literature: British Journal of Pharmacology, , vol. 132, # 6 p. 1183 - 1192

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Atorvastatin methyl ester Structure

Atorvastatin me...

CAS#:345891-62-5

Literature: Stach, Jan; Havlicek, Jaroslav; Placek, Lukas; Radl, Stanislav Collection of Czechoslovak Chemical Communications, 2008 , vol. 73, # 2 p. 229 - 246

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

methylester of atorvastatin
atorvastatin methyl ester
Atorvastatin Impurity 6