103772-13-0

• 常用中文名：1-环丙基-5-酰胺-6,7,8-三氟-1,4-二氢-4-氧代-3-喹啉羧酸乙酯
• 常用英文名：1-CYCLOPROPYL-5-AMIDO-6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3- QUINOLINECARBOXYLIC ACID ETHYL ESTER
• CAS号：103772-13-0
• 分子式：C₁₅H₁₃F₃N₂O₃
• 分子量：326.27100
• 发布时间：2018-08-18 11:43:54
• 更新时间：2026-07-01 19:51:50

名称

• 中文名: 1-环丙基-5-酰胺-6,7,8-三氟-1,4-二氢-4-氧代-3-喹啉羧酸乙酯
• 英文名: ethyl 5-amino-1-cyclopropyl-6,7,8-trifluoro-4-oxoquinoline-3-carboxylate
• 英文别名: ethyl 5 - amino - 1 - cyclopropyl - 6,7,8 - trifluoro - 4 - oxo - 1,4 - dihydroquinoline - 3 - cboxylate; Ethyl 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate; Valine Impurity; 1-Cyclopropyl-5-Amido-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic acid ethyl ester; ethyl 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate; 1-CYCLOPROPYL-5-AMIDO-6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3- QUINOLINECBOXYLIC ACID ETHYL ESTER; ethyl 5-amino-1-cyclopropyl-6,7,8-trifluoro-4(1H)-oxoquinoline-3-carboxylate; ethyl 1-cyclopropyl-5-amino-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

物化性质

• 分子式: C₁₅H₁₃F₃N₂O₃
• 分子量: 326.27100
• 精确质量: 326.08800
• PSA: 74.32000
• LogP: 3.09380

合成路线

110872-04-3 ~89% 103772-13-0

文献：Cociorva, Oana M.; Li, Bei; Nomanbhoy, Tyzoon; Li, Qiang; Nakamura, Ayako; Nakamura, Kai; Nomura, Masahiro; Okada, Kyoko; Seto, Shigeki; Yumoto, Kazuhiro; Liyanage, Marek; Zhang, Melissa C.; Aban, Arwin; Leen, Brandon; Szardenings, Anna Katrin; Rosenblum, Jonathan S.; Kozarich, John W.; Kohno, Yasushi; Shreder, Kevin R. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5948 - 5951

103772-12-9 ~99% 103772-13-0

文献：Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

107564-02-3 ~% 103772-13-0

文献：Miyamoto, Teruyuki; Matsumoto, Jun-ichi; Chiba, Katsumi; Egawa, Hiroshi; Shibamori, Koh-ichiro; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1645 - 1656

16583-08-7 ~% 103772-13-0

文献：Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

103772-10-7 ~% 103772-13-0

文献：Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

103772-11-8 ~% 103772-13-0

文献：Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

104885-01-0 ~% 103772-13-0

文献：Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

上下游产品

上游产品  7
110872-04-3 103772-12-9 107564-02-3 16583-08-7
103772-10-7 103772-11-8 104885-01-0
下游产品  3
110236-78-7 103772-14-1 110871-86-8