103772-14-1

• 常用中文名：5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid
• 常用英文名：5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid
• CAS号：103772-14-1
• 分子式：C₁₃H₉F₃N₂O₃
• 分子量：298.21700
• 发布时间：2017-03-29 09:46:23
• 更新时间：2025-08-26 03:38:59

名称

• 英文名: 5-amino-1-cyclopropyl-6,7,8-trifluoro-4-oxoquinoline-3-carboxylic acid
• 英文别名: 1-Cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxo-quinoline-3-carboxylic acid; 1-cyclopropyl-5-amino-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid L; 1-cyclopropyl-5-amino-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinoline-carboxylic acid; ORBIFLOXACIN; Orbax; 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid; 1-cyclopropyl-5,6,8-trifluoro-7-(cis-3,5-dimethyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid; 1-Cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(cis-3,5-dimethylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; 1-cyclopropyl-5-amino-6,7,8-trifluoro-4-oxo-1,4-dihydroquinolin-3-carboxylic acid

物化性质

• 密度: 1.762g/cm3
• 沸点: 512.4ºC at 760mmHg
• 分子式: C₁₃H₉F₃N₂O₃
• 分子量: 298.21700
• 闪点: 263.7ºC
• 精确质量: 298.05700
• PSA: 85.32000
• LogP: 2.61530
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.68

合成路线

103772-13-0 ~97% 103772-14-1

文献：Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

110872-04-3 ~93% 103772-14-1

文献：Miyamoto, Teruyuki; Matsumoto, Jun-ichi; Chiba, Katsumi; Egawa, Hiroshi; Shibamori, Koh-ichiro; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1645 - 1656

107564-02-3 ~% 103772-14-1

文献：Cociorva, Oana M.; Li, Bei; Nomanbhoy, Tyzoon; Li, Qiang; Nakamura, Ayako; Nakamura, Kai; Nomura, Masahiro; Okada, Kyoko; Seto, Shigeki; Yumoto, Kazuhiro; Liyanage, Marek; Zhang, Melissa C.; Aban, Arwin; Leen, Brandon; Szardenings, Anna Katrin; Rosenblum, Jonathan S.; Kozarich, John W.; Kohno, Yasushi; Shreder, Kevin R. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5948 - 5951

103772-12-9 ~% 103772-14-1

文献：Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

16583-08-7 ~% 103772-14-1

文献：Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

103772-10-7 ~% 103772-14-1

文献：Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

103772-11-8 ~% 103772-14-1

文献：Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

104885-01-0 ~% 103772-14-1

文献：Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

上下游产品

上游产品  8
103772-13-0 110872-04-3 107564-02-3 103772-12-9
16583-08-7 103772-10-7 103772-11-8 104885-01-0
下游产品  2
110236-78-7 110871-86-8