64019-03-0

• 常用中文名：多夸司特
• 常用英文名：Doqualast
• CAS号：64019-03-0
• 分子式：C₁₃H₈N₂O₃
• 分子量：240.21400
• 发布时间：2018-04-10 08:00:00
• 更新时间：2025-08-25 12:46:41

名称

• 中文名: 多夸司特
• 英文名: 11-oxopyrido[2,1-b]quinazoline-2-carboxylic acid
• 英文别名: Docualast [Spanish]; SM 857SE; Doqualastum [Latin]; 11-oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid; Doqualast; 11H-11-oxo-pyrido [2,1-b]quinazoline-2-carboxylic acid; SM 857; 11-Oxo-11H-pyrido(2,1-b)quinazolone-2-carboxylic acid

物化性质

• 密度: 1.46g/cm3
• 沸点: 524.4ºC at 760 mmHg
• 分子式: C₁₃H₈N₂O₃
• 分子量: 240.21400
• 闪点: 271ºC
• 精确质量: 240.05300
• PSA: 71.67000
• LogP: 1.54590
• 折射率: 1.715

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UV1176750 CHEMICAL NAME : 11H-Pyrido(2,1-b)quinazolone-2-carboxylic acid, 11-oxo- CAS REGISTRY NUMBER : 64019-03-0 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C13-H8-N2-O3 MOLECULAR WEIGHT : 240.23 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #3902639 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #3902639 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 4400 mg/kg SEX/DURATION : multigeneration TOXIC EFFECTS : Reproductive - Maternal Effects - parturition Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - eye/ear REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 38,351,1988 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 4400 mg/kg SEX/DURATION : multigeneration TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities Reproductive - Effects on Newborn - live birth index (measured after birth) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 38,351,1988 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 4400 mg/kg SEX/DURATION : multigeneration TOXIC EFFECTS : Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 38,351,1988

安全

• 海关编码: 2933990090

合成路线

201230-82-2 71937-21-8 ~47% 64019-03-0

文献：Tilley; LeMahieu; Carson; Kierstead; Baruth; Yaremko Journal of Medicinal Chemistry, 1980 , vol. 23, # 1 p. 92 - 95

上下游产品

上游产品  2
201230-82-2 71937-21-8
下游产品  0

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%