86-12-4

• 常用中文名：西那利定
• 常用英文名：thenalidine
• CAS号：86-12-4
• 分子式：C₁₇H₂₂N₂S
• 分子量：286.43500
• 相关类别： 原料药 抗变态反应药 过敏反应介质阻滞剂
• 发布时间：2018-02-26 08:00:00
• 更新时间：2024-01-22 16:21:49

名称

• 中文名: 西那利定
• 英文名: 1-methyl-N-phenyl-N-(thiophen-2-ylmethyl)piperidin-4-amine
• 英文别名: N-(1-Methyl-[4]piperidyl)-N-[2]thienylmethyl-anilin; 1-Methyl-4-N-2-thenylanilinopiperidine; Sandosten (4-Amino-1-methyl-N'-phenyl-N'-then-2-yl-piperidin-tartrat); Sanbosten; Tenalidina [INN-Spanish]; N-(1-methyl-[4]piperidyl)-N-[2]thienylmethyl-aniline; Thenalidinum; Thenalidinum [INN-Latin]; Tenalidina; thenalidine; 1-Methyl-4-<phenyl-<2-thenyl-amino>-piperidin; Thenophenopiperidine; N-Methyl-4-(N-thenyl-2-anilino)-piperidin; Thenaldine; 1-Methyl-4-amino-N-phenyl-N-(2-thenyl)piperidine

物化性质

• 密度: 1.14g/cm3
• 沸点: 413.9ºC at 760 mmHg
• 熔点: 95-97°
• 分子式: C₁₇H₂₂N₂S
• 分子量: 286.43500
• 闪点: 204.1ºC
• 精确质量: 286.15000
• PSA: 34.72000
• LogP: 3.78680
• 折射率: 1.619

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TN1400000 CHEMICAL NAME : Piperidine, 1-methyl-4-(N-2-thenylanilino)- CAS REGISTRY NUMBER : 86-12-4 BEILSTEIN REFERENCE NO. : 0244448 LAST UPDATED : 199709 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C17-H22-N2-S MOLECULAR WEIGHT : 286.47 WISWESSER LINE NOTATION : T6NTJ A1 DNR&1- BT5SJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1060 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 21,233,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 42 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 21,233,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 165 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 21,233,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 42 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 21,233,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 430 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MEWEAC Medizinische Welt. (F.K. Schattauer Verlag, Postfach 2945, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1-18, 1927-1944; V.1- 1950- Volume(issue)/page/year: 17,2791,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 21,233,1963

安全

• 海关编码: 2934999090

合成路线

108-86-1 100051-94-3 ~% 86-12-4

文献：Sandoz Patent: US2757175 , 1954 ; Full Text Show Details Sandoz Patent: DE1018420 , 1954 ;

765-50-4 22261-94-5 ~% 86-12-4

文献：Sandoz Patent: US2717251 , 1952 ; Full Text Show Details Sandoz Patent: DE961348 , 1952 ;

上下游产品

上游产品  4
108-86-1 100051-94-3 765-50-4 22261-94-5
下游产品  1
6846-13-5

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%