74436-00-3

• 常用中文名：吉环孢素
• 常用英文名：Geclosporin
• CAS号：74436-00-3
• 分子式：C₆₃H₁₁₃N₁₁O₁₂
• 分子量：1216.64000
• 发布时间：2018-09-29 18:19:34
• 更新时间：2025-09-13 20:33:00

名称

• 中文名: 吉环孢素
• 英文名: Geclosporin
• 英文别名: Cyclo(((2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl)-L-norvalyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl); cyclosporin G; (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Nva-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-); Cyclosporin A,7-L-norvaline; Cyclosporin Impurity 7

物化性质

• 密度: 1.013g/cm3
• 沸点: 1297.8ºC at 760 mmHg
• 分子式: C₆₃H₁₁₃N₁₁O₁₂
• 分子量: 1216.64000
• 闪点: 738.7ºC
• 精确质量: 1215.86000
• PSA: 278.80000
• LogP: 4.53960
• 折射率: 1.467

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GZ4130000 CHEMICAL NAME : Cyclosporin A, 7-L-norvaline- CAS REGISTRY NUMBER : 74436-00-3 LAST UPDATED : 199506 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C63-H113-N11-O12 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 420 mg/kg/28D-I TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal - other changes REFERENCE : TRPLAU Transplantation. (Williams & Wilkins, Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1963- Volume(issue)/page/year: 57,1231,1994