Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Cyclosporin G
Price: Check
Purity: 95.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Cyclosporine G
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Nanjing Peptide Biotech Ltd
China
Product Name: Geclosporin
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom
Email: chenglong.fan@njpeptide.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: C-(3,4-DICHLORO-PHENYL)-C-PHENYL-METHYLAMINEHYDROCHLORIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

74436-00-3

74436-00-3 structure

74436-00-3 structure

Name: Geclosporin
Chemical Name: Geclosporin
CAS Number: 74436-00-3
Molecular Formula: C₆₃H₁₁₃N₁₁O₁₂
Molecular Weight: 1216.64000
Create Date: 2018-09-29 18:19:34
Modify Date: 2024-01-12 05:14:36

Name	Geclosporin
Synonyms	Cyclo(((2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl)-L-norvalyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl) cyclosporin G (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Nva-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-) Cyclosporin A,7-L-norvaline Cyclosporin Impurity 7

Density	1.013g/cm3
Boiling Point	1297.8ºC at 760 mmHg
Molecular Formula	C₆₃H₁₁₃N₁₁O₁₂
Molecular Weight	1216.64000
Flash Point	738.7ºC
Exact Mass	1215.86000
PSA	278.80000
LogP	4.53960
Index of Refraction	1.467

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ4130000

CHEMICAL NAME :: Cyclosporin A, 7-L-norvaline-

CAS REGISTRY NUMBER :: 74436-00-3

LAST UPDATED :: 199506

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C63-H113-N11-O12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 420 mg/kg/28D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal - other changes

REFERENCE :: TRPLAU Transplantation. (Williams & Wilkins, Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1963- Volume(issue)/page/year: 57,1231,1994

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