4757-55-5

• 常用中文名：二甲他林
• 常用英文名：Dimetacrine
• CAS号：4757-55-5
• 分子式：C₂₀H₂₆N₂
• 分子量：294.43400
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-04-05 08:00:00
• 更新时间：2024-01-03 11:26:47
• Dimetacrine 是一种有用的抗抑郁药,可用于治疗各种类型的抑郁症。

名称

• 中文名: 二甲他林
• 英文名: 3-(9,9-dimethylacridin-10-yl)-N,N-dimethylpropan-1-amine
• 英文别名: Dimetacrinum; Dimetacrinum [INN-Latin]; Dimetacrine; Dimethacrine; [3-(9,9-dimethyl-9H-acridin-10-yl)-propyl]-dimethyl-amine; Dimetacrina [DCIT]; 10-(8-Dimethylaminopropyl)-5,5-dimethylacridan; Dimetacrine [INN]; 10-(3-Dimethylaminopropyl)-5,5-dimethylacridan; Dimetacrino; Dimethacrin; 9,9-Dimethyl-N-<3-(dimethyl-amino)-propyl>-acridan

物化性质

• 密度: 1.015 g/cm3
• 沸点: 406.4ºC at 760mmHg
• 分子式: C₂₀H₂₆N₂
• 分子量: 294.43400
• 闪点: 180.4ºC
• 精确质量: 294.21000
• PSA: 6.48000
• LogP: 4.48070
• 折射率: 1.559
• 储存条件: 2-8℃
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:2

  4.可旋转化学键数量:4

  5.互变异构体数量:无

  6.拓扑分子极性表面积:6.5

  7.重原子数量:22

  8.表面电荷:0

  9.复杂度:337

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: Dimetacrine 是一种有用的抗抑郁药,可用于治疗各种类型的抑郁症。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体内研究: Dimetacrine是一种有用的抗抑郁药,可用于治疗各种类型的抑郁症。最高浓度的Dimetacrine,10μM,收缩力降低至36.5±9.1％。 0.3μm的Dimetacrine不会引起对照组收缩力的统计学显着下降。在施用Dimetacrine后静脉注射1至3mg/kg静脉注射心动过速,并且以3mg/kg iv的剂量获得最大响应。给予Dimetacrine,30 mg/kg静脉注射,导致心动过速或心动过缓导致血压骤降,然后心脏骤停。输注Dimetacrine后40分钟呼吸频率增加。输注Dimetacrine后动脉血压下降50分钟[1]。
• 动物实验: 使用体重8至13kg的成年雄性杂种狗并用戊巴比妥钠麻醉，35mg / kg iv通过放置在胸腹区域周围的手风琴式呼吸描记器和压力传感器测量呼吸运动。对于单次静脉注射的实验，增加剂量的Dimetacrine，0.1,0.3,1,3,10和30 mg / kg静脉注射，直到心脏骤停发生，进入空心管左侧头静脉并用1 mL冲洗。生理盐水。 IMP，AMT和Dimetacrine对每种剂量引起的动脉血压和心率的变化进行了估计[1]。
• 参考文献:

  [1]. Kato H, et al. Comparison of cardiovascular toxicities induced by dimetacrine, imipramine and amitriptyline in isolated guinea pig atria and anesthetized dogs. Jpn J Pharmacol. 1974 Dec;24(6):885-91.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AR6973200 CHEMICAL NAME : Acridan, 9,9-dimethyl-10-(3-(dimethylamino)propyl)- CAS REGISTRY NUMBER : 4757-55-5 BEILSTEIN REFERENCE NO. : 1349663 LAST UPDATED : 199712 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C20-H26-N2 MOLECULAR WEIGHT : 294.48 WISWESSER LINE NOTATION : T C666 BM IHJ B3 M1&1 I1 I1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1850 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 181 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1076 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1293 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 206 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 676 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 39600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 910 mg/kg/13W-C TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - changes in prostate weight Related to Chronic Data - changes in testicular weight REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,949,1974 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 91 mg/kg SEX/DURATION : male 91 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,949,1974

安全

• 海关编码: 2942000000

海关

海关编码	2942000000