| 中文名 |
多粘菌素E
|
| 英文名 |
colistin
|
| 中文别名 |
抗敌素
|
| 英文别名 |
colistin
|
| 描述 |
粘菌素(多粘菌素E)是一种口服活性多肽抗生素,对多种革兰氏阴性杆状细菌具有优异的活性,包括耐多药铜绿假单胞菌、鲍曼不动杆菌和肺炎克雷伯菌。粘菌素(多粘菌素E)与肾毒性有关,可用于研究革兰氏阴性杆菌引起的感染[1][2]。
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| 相关类别 |
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| 体内研究 |
粘菌素(多粘菌素E)(16 mg/kg/天,i.p.)显示细胞周期阻滞基因的富集,表明粘菌素引起的损伤或细胞应激通过p53抑制细胞周期进展。粘菌素(多粘菌素E)(16 mg/kg/天,i.p.)具有升高的血尿素氮(BUN)、肌酐和急性肾小管坏死和凋亡的病理证据[1]。动物模型：C57/BL6小鼠[1]剂量：16 mg/kg/天给药：16 mg/kg/天,腹腔注射。结果：检测小鼠凋亡、坏死和PCNA染色。
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| 参考文献 |
[1]. Silpak Biswas, et al. Colistin: an update on the antibiotic of the 21st century. Expert Rev Anti Infect Ther. 2012 Aug;10(8):917-34. [2]. Jian Li, et al. Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate. [3]. Michael T Eadon, et al. Cell cycle arrest in a model of colistin nephrotoxicity. Physiol Genomics. 2013 Oct 1;45(19):877-88.
|
| 密度 |
1.25g/cm3 |
| 沸点 |
1536.8ºC at 760mmHg |
| 分子式 |
C52H98N16O13 |
| 分子量 |
1155.43000 |
| 闪点 |
883.3ºC |
| 精确质量 |
1154.75000 |
| PSA |
490.66000 |
| LogP |
1.53520 |
| 蒸汽压 |
0mmHg at 25°C |
| 折射率 |
1.573 |
| 储存条件 |
库房通风低温干燥,与食品原料分开储运 |
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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GH1575000
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CHEMICAL NAME :
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Colistin
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CAS REGISTRY NUMBER :
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1066-17-7
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LAST UPDATED :
-
199806
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DATA ITEMS CITED :
-
14
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MOLECULAR FORMULA :
-
C45-H85-N13-O10
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MOLECULAR WEIGHT :
-
968.43
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WISWESSER LINE NOTATION :
-
T-24-MV DMV GMV JMV MMV PMV SMV VMVTJ CYQ1 F2MV4Y2&1 I1Y1&1 L2Z O1Y1&1 R2Z U2Z A&2Z
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>2 gm/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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236 mg/kg
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TOXIC EFFECTS :
-
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity
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TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
-
115 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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8800 ug/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Mammal - cat
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DOSE/DURATION :
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250 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - nausea or vomiting
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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100 mg/kg
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TOXIC EFFECTS :
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Peripheral Nerve and Sensation - flaccid paralysis with appropriate anesthesia Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Subcutaneous
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SPECIES OBSERVED :
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Mammal - cat
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DOSE/DURATION :
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1500 mg/kg/30D-I
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA
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TYPE OF TEST :
-
Cytogenetic analysis
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TEST SYSTEM :
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Human Lymphocyte
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DOSE/DURATION :
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142 units/ml
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REFERENCE :
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TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 3,515,1983 *** REVIEWS *** TOXICOLOGY REVIEW MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.) V.33-115, 1886-1973. Volume(issue)/page/year: 115,1661,1973 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5828 No. of Facilities: 143 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1941 (estimated) No. of Female Employees: 1403 (estimated)
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| 危险品运输编码 |
UN 3249 |
| 包装等级 |
III |
| 危险类别 |
6.1(b) |
由多粘杆菌（Bacillus Polymyxa）的培养液中提取。现有多粘菌素A、B、C、D、E五种，多粘菌素E 的主要成分是多粘菌素E1，含少量多粘菌素E2。
