19395-58-5

• 常用中文名：吗喹酮
• 常用英文名：moquizone
• CAS号：19395-58-5
• 分子式：C₂₀H₂₁N₃O₃
• 分子量：351.39900
• 发布时间：2018-07-30 12:45:15
• 更新时间：2024-01-12 10:09:48

名称

• 中文名: 吗喹酮
• 英文名: 1-(2-morpholin-4-ylacetyl)-3-phenyl-2H-quinazolin-4-one
• 英文别名: Moquizonum [INN-Latin]; Mochizone [DCIT]; 1-Morpholinoacetyl-3-phenyl-4-oxo-1,2,3,4-tetrahydrochinazolin; 2,3-Dihydro-1-(morpholinoacetyl)-3-phenyl-4(1H)-quinazolinone; 1-(morpholin-4-yl-acetyl)-3-phenyl-2,3-dihydro-1H-quinazolin-4-one; Moquizone [INN]; 1-Morpholinomethylcarbonyl-3-phenyl-2,3-dihydro-4(1H)-chinazolinon; EINECS 243-021-2; Moquizone; 4(1H)-Quinazolinone,2,3-dihydro-1-(morpholinoacetyl)-3-phenyl; Moquizona [INN-Spanish]; 4(1H)-Quinazolinone,2,3-dihydro-1-(4-morpholinyacetyl)-3-phenyl

物化性质

• 密度: 1.278g/cm3
• 沸点: 599.9ºC at 760 mmHg
• 分子式: C₂₀H₂₁N₃O₃
• 分子量: 351.39900
• 闪点: 316.6ºC
• 精确质量: 351.15800
• PSA: 53.09000
• LogP: 2.03760
• 蒸汽压: 2.37E-14mmHg at 25°C
• 折射率: 1.618

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VA3150000 CHEMICAL NAME : 4(1H)-Quinazolinone, 2,3-dihydro-1-(morpholinoacetyl)-3-phenyl- CAS REGISTRY NUMBER : 19395-58-5 LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C20-H21-N3-O3 MOLECULAR WEIGHT : 351.44 WISWESSER LINE NOTATION : T66 BVN EN DHJ CR& EV1- AT6N DOTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2220 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Vascular - regional or general arteriolar or venous dilation Lungs, Thorax, or Respiration - other changes REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,571,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 146 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,571,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 930 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - changes in structure or function of salivary glands REFERENCE : JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 22,235,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 559 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,571,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 774 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,571,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 237 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,571,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1730 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Vascular - regional or general arteriolar or venous dilation Lungs, Thorax, or Respiration - other changes REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,571,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,571,1970