27035-30-9

• 常用中文名：奥沙美辛
• 常用英文名：Oxametacin
• CAS号：27035-30-9
• 分子式：C₁₉H₁₇ClN₂O₄
• 分子量：372.80200
• 发布时间：2018-09-16 18:35:30
• 更新时间：2025-09-05 19:57:00
• Oxametacin is a anti-inflammatory compound used with care in anticoagulated patients. It has analgesic, antipyretic and anti-inflammatory properties comparable to those of indomethacin.

名称

• 中文名: 奥沙美辛
• 英文名: oxametacin
• 英文别名: Oxametacinum [INN-Latin]; Oxametacine [INN-French]; Oxametacin; 2-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-indol-3-yl]-N-hydroxy-acetamide; Oxametacin [INN]; Acido indoxamico [Italian]; Indoxamic acid; 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-hydroxyacetamide; Oxametacine; 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl}ethanehydroxamic acid; Oxametacina [INN-Spanish]; 1-(4-chloro-benzoyl)-5-methoxy-2-methyl-3-indolyl-acetohydroxamic acid; Oxamethacin; 1-(p-chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetohydroxamic acid; Flogar

物化性质

• 密度: 1.35g/cm3
• 分子式: C₁₉H₁₇ClN₂O₄
• 分子量: 372.80200
• 精确质量: 372.08800
• PSA: 80.56000
• LogP: 3.73900
• 折射率: 1.63

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NL3668500 CHEMICAL NAME : Indole-3-acetohydroxamic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl- CAS REGISTRY NUMBER : 27035-30-9 BEILSTEIN REFERENCE NO. : 0497721 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C19-H17-Cl-N2-O4 MOLECULAR WEIGHT : 372.83 WISWESSER LINE NOTATION : T56 BNJ BVR DG& C1 D1VMQ GO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 78 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,319,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,319,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 92 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,319,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 32 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,319,1975

安全

• 海关编码: 2933990090

合成路线

20357-37-3 ~% 27035-30-9

文献：Wey, Shiow-Jyi; Augustyniak, Michael E.; Cochran, Edward D.; Ellis, James L.; Fang, Xinqin; Garvey, David S.; Janero, David R.; Letts, L. Gordon; Martino, Allison M.; Melim, Terry L.; Murty, Madhavi G.; Richardson, Steward K.; Schroeder, Joseph D.; Selig, William M.; Trocha, A. Mark; Wexler, Roseanne S.; Young, Delano V.; Zemtseva, Irina S.; Zifcak, Brian M. Journal of Medicinal Chemistry, 2007 , vol. 50, # 25 p. 6367 - 6382

53-86-1 ~% 27035-30-9

文献：Flynn; Capiris; Cetenko; Connor; Dyer; Kostlan; Nies; Schrier; Sircar Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2070 - 2072

上下游产品

上游产品  2
20357-37-3 53-86-1
下游产品  0

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%