品牌现货直购
供应商:我要出现这里



查看所有供应商和价格请点击:

7059-24-7生产厂家

7059-24-7价格

7059-24-7

7059-24-7结构式
7059-24-7结构式
  • 常用中文名:色霉素A3
  • 常用英文名:Chromomycin A3
  • CAS号:7059-24-7
  • 分子式:C57H82O26
  • 分子量:1183.25000
  • 相关类别: 原料药 抗肿瘤药 抗生素类抗肿瘤药
  • 发布时间:2018-03-13 08:00:00
  • 更新时间:2024-01-11 16:05:12
  • Chromomycin A3 是一种金黄色素型抗肿瘤抗生素。Chromomycin A3 与二价阳离子形成二聚体复合物,例如 Mg2+,其强烈结合富含 GC 的 DNA 序列以抑制 DNA 复制和转录。Chromomycin A3 具有多种用途,可作为人精子染色质,自噬诱导剂和凋亡抑制剂的染色剂。

化源商城直购

中文名 色霉素A3
英文名 chromomycin A3
中文别名 铬霉菌素A3
东洋霉素
英文别名 MFCD00043151
Chromoycin A3
antibioticb599
EINECS 230-348-0
TOYOMYCIN
Olivomycin D
CHROMOMYCIN A3
Chromomycin
aburamycinb
描述 Chromomycin A3 是一种金黄色素型抗肿瘤抗生素。Chromomycin A3 与二价阳离子形成二聚体复合物,例如 Mg2+,其强烈结合富含 GC 的 DNA 序列以抑制 DNA 复制和转录。Chromomycin A3 具有多种用途,可作为人精子染色质,自噬诱导剂和凋亡抑制剂的染色剂。
相关类别
参考文献

[1]. Murase H, et al. Evaluation of simultaneous binding of Chromomycin A3 to the multiple sites of DNA by the new restriction enzyme assay. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1832-1835.

密度 1.43g/cm3
沸点 1147.6ºC at 760 mmHg
熔点 185℃
分子式 C57H82O26
分子量 1183.25000
闪点 311.1ºC
精确质量 1182.51000
PSA 359.34000
LogP 1.54640
外观性状 黄色粉末
折射率 1.608
储存条件

一、贮存

2-8°储存。

分子结构

1、 摩尔折射率:286.26

2、 摩尔体积(m3/mol):827.2

3、 等张比容(90.2K):2394.9

4、 表面张力(dyne/cm):70.2

5、 极化率(10-24cm3):113.48

更多

一、物性数据

性状:不可用

密度(g/mL,25/4℃):不可用

相对蒸汽密度(g/mL,空气=1):不可用

熔点(ºC):不可用

沸点(ºC,常压):不可用

沸点(ºC,5.2kPa):不可用

折射率:不可用

闪点(ºC):不可用

比旋光度(º):不可用

自燃点或引燃温度(ºC):不可用

蒸气压(kPa,25ºC):不可用

饱和蒸气压(kPa,60ºC):不可用

燃烧热(KJ/mol):不可用

临界温度(ºC):不可用

临界压力(KPa):不可用

油水(辛醇/水)分配系数的对数值:不可用

爆炸上限(%,V/V):不可用

爆炸下限(%,V/V):不可用

溶解性:不可用

毒理学数据:

二、毒理学数据:

急性毒性:不可用。

生态学数据:

三、生态学数据:

1、其它有害作用:该物质对环境可能有危害,对水体应给予特别注意。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GB7875000
CHEMICAL NAME :
Chromomycin A3
CAS REGISTRY NUMBER :
7059-24-7
LAST UPDATED :
199806
DATA ITEMS CITED :
28
MOLECULAR FORMULA :
C57-H82-O26
MOLECULAR WEIGHT :
1183.39
WISWESSER LINE NOTATION :
L C666 DVT&&J BQ FYO1&VYQYQ1 M1 NQ LO- BT6OTJ DOV1 F1 EO- BT6OTJ DQ EO1 F1&& EO- BT6OTJ EQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1431 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
200 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - coma Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
330 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - coma Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
500 ug/kg/5D-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Blood - other changes Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
750 ug/kg/5D-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Liver - fatty liver degeneration Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
250 ug/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
125 ug/kg
SEX/DURATION :
female 6-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - eye/ear
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
500 ug/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
125 ug/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,2813,1985 *** REVIEWS *** TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965

符号 GHS06 GHS08
GHS06, GHS08
信号词 Danger
危害声明 H300-H360
警示性声明 P201-P264-P301 + P310-P308 + P313
个人防护装备 Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲) T+,T
风险声明 (欧洲) 61-28
安全声明 (欧洲) S28;S45;S53;S36/S37/S39
危险品运输编码 UN 3462 6.1/PG 1
WGK德国 3
RTECS号 GB7875000
包装等级 I
危险类别 6.1(a)