| 中文名 | 氨甲蝶呤 |
|---|---|
| 英文名 | (+/-)amethopterin |
| 中文别名 | (+/-)氨甲喋呤 |
| 英文别名 |
amethopterin
4-amino-N10-methylpteroylglutamic acid EINECS 262-213-7 MFCD00150845 4-amino-10-methylpteroyl-glutamic acid D-methionine-R-sulfoximine D-Methotrexat 2S,5S-Methionine sulfoximine |
| 密度 | 1.536 g/cm3 |
|---|---|
| 熔点 | 195ºC (dec.)(lit.) |
| 分子式 | C20H22N8O5 |
| 分子量 | 454.43900 |
| 精确质量 | 454.17100 |
| PSA | 210.54000 |
| LogP | 1.82170 |
| 外观性状 | 黄色至橙色结晶粉末 |
| 储存条件 | 充氩气密闭于−20°C阴凉干燥环境中 |
| 稳定性 | 1.遵照规定使用和储存则不会分解。 2.有毒，能引起遗传基因的损伤，可能危害胎儿，使用时应穿适当的防护服，避免了暴露。 |
| 分子结构 | 1、 摩尔折射率：118.97 2、 摩尔体积（cm3/mol）：295.6 3、 等张比容（90.2K）：926.7 4、 表面张力（dyne/cm）：96.4 5、 极化率（10-24cm3）：47.16 |
| 计算化学 | 1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:5 3.氢键受体数量:12 4.可旋转化学键数量:9 5.互变异构体数量:24 6.拓扑分子极性表面积211 7.重原子数量:33 8.表面电荷:0 9.复杂度:704 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:1 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1 |
| 更多 | 1. 性状：橙黄色结晶性粉末 2. 密度（g/mL,25/4℃）：无可用 3. 相对蒸汽密度（g/mL,空气=1）：无可用 4. 熔点（ºC）：195 5. 沸点（ºC,常压）：无可用 6. 沸点（ºC,5.2kPa）：无可用 7. 折射率：无可用 8. 闪点（ºC）：无可用 9. 比旋光度（º）：无可用 10. 自燃点或引燃温度（ºC）：无可用 11. 蒸气压（kPa,25ºC）：无可用 12. 饱和蒸气压（kPa,60ºC）：无可用 13. 燃烧热（KJ/mol）：无可用 14. 临界温度（ºC）：无可用 15. 临界压力（KPa）：无可用 16. 油水（辛醇/水）分配系数的对数值：无可用 17. 爆炸上限（%,V/V）：无可用 18. 爆炸下限（%,V/V）：无可用 19. 溶解性：易溶于稀碱；酸或碱金属的碳酸盐溶液，微溶于稀盐酸，几乎不溶于水、乙醇、氯仿和乙醚 |
Synonym:DL-Amethopterin Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 46 61 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
May cause heritable genetic damage. May cause harm to the unborn child.Hygroscopic (absorbs moisture from the air).Light sensitive.The toxicological properties of this material have not been fully investigated.Mutagen. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. May be absorbed through the skin in harmful amounts. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Exposure may cause anemia and other blood abnormalities. Inhalation: May cause respiratory tract irritation. May cause effects similar to those described for ingestion. The toxicological properties of this substance have not been fully investigated. Chronic: May alter genetic material. Possible risk of harm to the unborn child. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light. Storage: Store in a tightly closed container. Deep freeze (below -20C). Store protected from moisture. Store protected from light. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 60388-53-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: orange - yellow crystalline powder Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 195 deg C dec Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: > 195 deg C Solubility in water: Specific Gravity/Density: Molecular Formula: C20H22N8O5.xH2O Molecular Weight: 454.44 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Incompatible materials, light, dust generation, excess heat, exposure to moist air or water. Incompatibilities with Other Materials: Strong acids, strong oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, oxides of nitrogen, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 60388-53-6: MA1224100 LD50/LC50: Not available. Carcinogenicity: DL-Amethopterin hydrate - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: TOXIC SOLID, ORGANIC, N.O.S. Hazard Class: 6.1 UN Number: 2811 Packing Group: III IMO Shipping Name: TOXIC SOLID, ORGANIC, N.O.S. Hazard Class: 6.1 UN Number: 2811 Packing Group: III RID/ADR Shipping Name: TOXIC SOLID, ORGANIC, N.O.S. Hazard Class: 6.1 UN Number: 2811 Packing group: III Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: T Risk Phrases: R 46 May cause heritable genetic damage. R 61 May cause harm to the unborn child. Safety Phrases: S 53 Avoid exposure - obtain special instructions before use. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 60388-53-6: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 60388-53-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 60388-53-6 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
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生态学数据: 该物质对环境可能有危害，对水体应给予特别注意。
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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