24465-45-0

• 常用中文名：Normeperidine hydrochloride
• 常用英文名：Normeperidine hydrochloride (Norpethidine)
• CAS号：24465-45-0
• 分子式：C₁₄H₂₀ClNO₂
• 分子量：269.76700
• 发布时间：2018-12-28 06:53:49
• 更新时间：2024-02-01 18:22:53
• Normeperidine hydrochloride is a certified reference material that is structurally categorized as an opioid.

名称

• 中文名: 4-苯基-4-乙氧甲酰哌啶盐酸盐
• 英文名: normeperidine
• 中文别名: 4-苯基哌啶-4-甲酸乙酯盐酸盐
• 英文别名: 4-Phenyl-piperidine-4-carboxylic acid ethyl ester hydrochloride; 4-PIPERIDINECARBOXYLIC ACID,4-PHENYL-,ETHYL ESTER HYDROCHLORIDE; 4-Carboethoxy-4-phenylpiperidine hydrochloride; 4-PHENYL-4-CARBETHOXY PIPERIDINE HCL; 4-CARBOETHOXY-4-PHENYLPIPERIDINE HCL; ethyl 4-phenylpiperidine-4-carboxylate hydrochloride; 4-Phenyl-piperidin-4-carbonsaeure-aethylester,Hydrochlorid; isonipecoticacid,4-phenyl-,ethylester,hydrochloride; ethyl 4-phenyl-4-piperidinecarboxylate HCl; Normeperidine hydrochloride; ethyl 4-phenyl-4-piperidinecarboxylate hydrochloride; normepiridinehydrochloride

物化性质

• 沸点: 333.5ºC at 760 mmHg
• 分子式: C₁₄H₂₀ClNO₂
• 分子量: 269.76700
• 闪点: 155.5ºC
• 精确质量: 269.11800
• PSA: 38.33000
• LogP: 3.00170
• 蒸汽压: 0.000136mmHg at 25°C
• 储存条件: -20°C，密闭，干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NS6195000 CHEMICAL NAME : Isonipecotic acid, 4-phenyl-, ethyl ester, hydrochloride CAS REGISTRY NUMBER : 24465-45-0 LAST UPDATED : 199012 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C14-H19-N-O2.Cl-H MOLECULAR WEIGHT : 269.80 WISWESSER LINE NOTATION : T6MTJ DVO2 DR &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 84 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 112,191,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 63 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#12033

安全

• 危害码 (欧洲): F: Flammable;T: Toxic;
• 风险声明 (欧洲): R11
• 安全声明 (欧洲): 7-16-36/37-45
• 危险品运输编码: UN 1230 3/PG 2
• 海关编码: 2933399090

合成路线

51304-58-6 ~% 24465-45-0

文献：Pfizer Inc Patent: US5936089 A1, 1999 ;

142851-03-4 ~% 24465-45-0

文献：Axford, Lorraine C.; Agarwal, Piyush K.; Anderson, Kelly H.; Andrau, Laura N.; Atherall, John; Barker, Stephanie; Bennett, James M.; Blair, Michael; Collins, Ian; Czaplewski, Lloyd G.; Davies, David T.; Gannon, Carlie T.; Kumar, Dushyant; Lancett, Paul; Logan, Alastair; Lunniss, Christopher J.; Mitchell, Dale R.; Offermann, Daniel A.; Palmer, James T.; Palmer, Nicholas; Pitt, Gary R.W.; Pommier, Stephanie; Price, Daniel; Narasinga Rao; Saxena, Rashmi; Shukla, Tarun; Singh, Amit K.; Singh, Mahipal; Srivastava, Anil; Steele, Christopher; Stokes, Neil R.; Thomaides-Brears, Helena B.; Tyndall, Edward M.; Watson, David; Haydon, David J. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6598 - 6603

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%